Chronic Diarrhea Owing to Underlying Microscopic Colitis

The goal of this observational study is to search for accurate diagnoses for patients with chronic diarrhea and assess the prevalence of microscopic colitis. The main question[s] it aims to answer [is/are]:

Does microscopic colitis account for a significant portion of patients with chronic diarrhea?

Participants will subjected to:

* Routine laboratory examination. * Colonoscopy: A total colonoscopy will be done with visualization of the terminal ileum. Biopsies will be taken from each segment of the colon and any abnormal appearing areas, the right-sided colon (cecum, ascending colon, and transverse colon), the left-sided colon (descending colon and sigmoid colon), and the rectum.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Chronic Diarrhea Colitis Colitis, Microscopic Colonic Diseases Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Intestinal Diseases Microscopic Colitis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Zagazig University Hospital

Zagazig, Sharqia Province, 44519, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with chronic watery diarrhea

Exclusion criteria

Infectious colitis.
Inflammatory bowel diseases (ulcerative colitis, Crohn's disease, and indeterminate colitis).
Systemic disease associated with chronic diarrhea, e.g. Diabetes mellitus and Thyroid disease.
Drugs causing chronic diarrhea, e.g. antibiotics, antidepressants, and angiotensin-converting enzyme inhibitors.
Chronic diarrhea of decreased digestion as in pancreatic insufficiency and bile acid deficiency.

Treatment and study plan

Primary outcomes

Number of Participants with Chronic Diarrhea Diagnosed with Microscopic Colitis

Time frame: 6 weeks

Diagnostic criteria for the diagnosis of microscopic colitis include increased chronic inflammatory infiltration in the lamina propria, increased intraepithelial lymphocytes (IELs), degeneration of surface epithelium, and increased mitosis in crypts.

Secondary outcomes

Rate of Lymphocytic and Collagenous Types of Microscopic Colitis in Individuals Experiencing Chronic Diarrhea

Time frame: 2 weeks

Over 20 IELs per 100 inter-cryptal epithelial cells (normal <1-5/100) were required for the diagnosis of lymphocytic colitis.

For collagenous colitis, subepithelial collagen band thickness was measured by ocular micrometer in specimens stained with Masson's Trichrome. Specimen thickness over 10 μm was required for the diagnosis.

Sponsors and collaborators

Lead sponsor

Zagazig University

Other Gov

Registry information

Official study title

Chronic Diarrhea Owing to Underlying Microscopic Colitis: Diagnosis Challenges and Size of the Problem

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2025
First posted: Jul 31, 2024
Registry last updated: Aug 2, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting