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OpenTrials
Completed

NCT Number: NCT02551276

Chronic Beta2-adrenergic Stimulation and Cardiac and Skeletal Muscle Hypertrophy

Studies in animals have shown that beta2-adrenoceptor activation with selective agonists regulates protein metabolism and muscle growth in skeletal and cardiac muscle tissue. These effects may be mediated by cAMP/PKA dependent activation of several downstream sites that modulate protein synthesis and breakdown. While the role of beta2-adrenoceptor signaling is well-described in animals, it is inadequately explored in humans. The purpose of the study is thus to investigate the effect of chronic beta2-adrenergic stimulation (cAMP/PKA-signaling) on muscle hypertrophy.

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Key information

Conditions

Muscle Hypertrophy in Healthy Young Men

Age range

18 year–40 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Physical active
  • Non-smokers
  • Non-asthmatics
  • No chronic diseases
  • Informed consent

Exclusion criteria

  • Smoker
  • Allergy towards study drug

Treatment and study plan

Salbutamol

Drug

Placebo

Drug

Resistance training

Other

Primary outcomes

  1. Skeletal Muscle Hypertrophy (lean body mass in Kilograms)

    Time frame: 2 days

    Lean body mass (kg) will be measured at two different days by Dual X-ray absorbance (DXA)

Secondary outcomes

  1. Left Ventricular Hypertrophy (mass in grams)

    Time frame: 1 day

    Left Ventricular Mass (g) will be measured by echocardiography of the heart

Sponsors and collaborators

Lead sponsor

University of Copenhagen

Other

Collaborators

  • Bispebjerg Hospital
  • University of Southern Denmark

Registry information

Official study title

Role of 11 Weeks of Beta2-adrenergic Signaling and Resistance Training for Cardiac and Skeletal Muscle Hypertrophy in Men

Important dates

Study start
2013
Primary completion
2014
Study completion
2015
First posted
Sep 16, 2015
Registry last updated
Mar 15, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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