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Completed

NCT Number: NCT00561028

Chlamydia and Mycoplasma in Coronary Artery Disease

To test the association between anti-Chlamydia serum titers and anti-Mycoplasma antibodies with Acute Coronary Syndromes.

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Key information

Conditions

Atherosclerosis Arterial Occlusive Diseases Arteriosclerosis Bacterial Infections Bacterial Infections and Mycoses Cardiovascular Diseases Chlamydia Infections Chlamydiaceae Infections Communicable Diseases Coronary Artery Disease Coronary Disease Genital Diseases Gram-Negative Bacterial Infections Heart Diseases Infections Mycoplasma Infections Mycoplasmatales Infections Myocardial Ischemia Sexually Transmitted Diseases Sexually Transmitted Diseases, Bacterial Urogenital Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

One hundred and twenty-six patients were divided into 4 groups: Acute Coronary Syndrome with ST-elevation, Non-ST-elevation, stable coronary artery disease, and individuals without coronary disease. Anti-Chlamydia and anti-Mycoplasma IgG antibodies were measured at baseline and after 6 months.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age >18 yrs
  • Males and females
  • Agreed to sign the informed consent

Exclusion criteria

  • Refusal to sign the informed consent
  • Follow-up not possible
  • For the "acute" groups, time between the pain beginning and randomization >24 hours
  • Active infections
  • Use of antimicrobial agents within the last 30 days
  • End-stage diseases with life expectancy <6 months

Treatment and study plan

blood sample analysis - mycoplasma and chlamydia antibodies

Other

Anti-Chlamydia and anti-Mycoplasma IgG antibodies were measured by indirect immunofluorescence at baseline (24 hours of hospitalization) and after 6 months (follow-up).

Primary outcomes

  1. Test the hypothesis that patients with acute coronary syndromes have higher levels of Chlamydia pneumonia and Mycoplasma pneumonia antibodies in comparison with patients with stable coronary artery disease or controls.

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Hospital de Base

Other

Collaborators

  • University of Sao Paulo

Registry information

Official study title

Prevalence of Chlamydia Pneumoniae and Mycoplasma Pneumoniae in Different Forms of Obstructive Coronary Artery Disease

Important dates

Study start
2002
Study completion
2004
First posted
Nov 20, 2007
Registry last updated
Nov 20, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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