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NCT Number: NCT06472674

China Healthy Aging Cohort Study

This is a community-based prospective cohort study in China. The study has been initialized in 2024 and included older residents. The goal of this observational study is to explore the risk factors related to disability and dementia in the elderly Chinese community population, and develop a risk prediction model for disability and dementia.

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Key information

Conditions

Age Problem Brain Diseases Central Nervous System Diseases Death Dementia Disability Mental Disorders Nervous System Diseases Neurocognitive Disorders Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

60 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Xuanwu Hospital, Capital Medical University

Beijing, 100053, China

Location status: Recruiting

Location contact

Yi Tang, M.D., Ph.D.

CONTACT

[email protected]

00861083199456

About this study

This is a community-based prospective cohort study in China. Individuals who were aged 60 years or older, had lived in the communities for more than 1 year, and had signed the informed consent form were enrolled in the present study. The study has been initiated in 2024 and aimed to explore the risk factors related to disability and dementia in the elderly Chinese population, and develop a risk prediction model for disability and dementia. This work consists of three steps as follows. First, by integrating the data of the elderly cohort of 4 communities in Beijing, Shenzhen, Haikou and Hangzhou, we plan to establish a Chinese elderly database. Second, to explore the risk factors of disability and dementia in elderly Chinese. Third, to construct risk prediction models of disability and dementia in Chinese elderly.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 60 years or older
  • Lived in the community for more than 1 year
  • Signed the informed consent form

Exclusion criteria

  • Cannot complete the survey

Treatment and study plan

No intervention

Other

No intervention

Primary outcomes

  1. The prevalence and incidence of functional disability using a population-based survey

    Time frame: An average of 1 to 2 years

    Functional disability was measured by Activities of Daily Living, cognitive function (Mini-Mental State Examination) and movement disorder（Short Physical Performance Battery) collected by questionnaires.The minimum value of the Activities of Daily Living is 0, and the maximum value is 100, the higher the score, the better the outcome.The minimum value of the Mini-Mental State Examination is 0, and the maximum value is 30, the higher the score, the better the outcome.The minimum value of the Short Physical Performance Battery is 0, and the maximum value is 12, the higher the score, the better the outcome.

  2. The prevalence and incidence of mild cognitive impairment using a population-based survey

    Time frame: An average of 1 to 2 years

    Mild cognitive impairment was measured using Mini-Mental State Examination collected by questionnaire.The minimum value of the Mini-Mental State Examination is 0, and the maximum value is 30, the higher the score, the better the outcome.

  3. The prevalence and incidence of dementia using a population-based survey

    Time frame: An average of 1 to 2 years

    Dementia was determined by diagnosis of hospitalization or diagnosis of death or Clinical Dementia Rating scale. The minimum value of the Clinical Dementia Rating is 0, and the maximum value is 3, the higher the score, the worse the outcome.

  4. The conversion rate of normal to mild cognitive impairment

    Time frame: An average of 1 to 2 years

    Percentage of enrolled population that convert from normal to mild cognitive impairment

  5. The conversion rate of mild cognitive impairment to dementia

    Time frame: An average of 1 to 2 years

    Percentage of enrolled population that convert from mild cognitive impairment to dementia

  6. The prevalence and incidence of movement disorder using a population-based survey

    Time frame: An average of 1 to 2 years

    Movement disorder was measured using Short Physical Performance Battery collected by questionnaire.The minimum value of the Short Physical Performance Battery is 0, and the maximum value is 12, the higher the score, the better the outcome.

Study contacts

Contact information is provided by the study sponsor or research team.

Yi Tang, MD., PhD

CONTACT

[email protected]

00861083199456

Sponsors and collaborators

Lead sponsor

Xuanwu Hospital, Beijing

Other

Registry information

Acronym: China-Ageing

Important dates

Study start
2024
Primary completion
2063
Study completion
2063
First posted
Jun 25, 2024
Registry last updated
Jun 25, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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