Children Born From IVM-CAPA vs IVF or Natural Conception

• ASQ-3 (Ages and Stages Questionares®) has 5 aspects: Communication, Gross motor, Fine motor, Problem solving and Personal-Social
• Each aspesct has 6 questions, if the answer is Yes, score = 10, Sometimes = 5 and Not yet = 0.
• ASQ-3 average = average score of 5 aspects.

• 6 questions, if the answer is Yes, score = 10, Sometimes = 5 and Not yet = 0.
• Total score will be used: minimum = 0 and maximum = 60.
• Each aspects in each stages has alternative threshold

• 6 questions, if the answer is Yes, score = 10, Sometimes = 5 and Not yet = 0.
• Total score will be used: minimum = 0 and maximum = 60.
• Each aspects in each stages has alternative threshold

• 6 questions, if the answer is Yes, score = 10, Sometimes = 5 and Not yet = 0.
• Total score will be used: minimum = 0 and maximum = 60.
• Each aspects in each stages has alternative threshold

• 6 questions, if the answer is Yes, score = 10, Sometimes = 5 and Not yet = 0.
• Total score will be used: minimum = 0 and maximum = 60.
• Each aspects in each stages has alternative threshold

• 6 questions, if the answer is Yes, score = 10, Sometimes = 5 and Not yet = 0.
• Total score will be used: minimum = 0 and maximum = 60.
• Each aspects in each stages has alternative threshold

• For children less than 4 months

• Rolling prior to 3 months
• Persistent fisting at 3 months
• Failure to alert to environmental stimuli
• For children from 4 to 6 months

• Poor head control
• Failure to reach for objects by 5 months
• Absent smile
• For children from 6 to 12 months

• Absent babbling by 6 months
• W-sitting at 7 months
• Inability to localize sound by 10 months
• Persistent mouthing of objects at 12 months
• Lack of consonant production by 15 months
• For children from 12 to 24 months

• Lack of imitation by 16 months
• Lack of protodeclarative pointing by 18 months
• Hand dominance prior to 18 months
• Inability to walk up and down stairs at 24 months
• Advanced non-communicative speech (meaningless communication repertoires)
• Delayed Language Development milestone (50 single words at 24 months)

Duration of breast-feeding

Infant age at which weaning starts

Diseases that lead to hospital admission

Number of hospital admission

Weight at 3, 6, 12, 18, 24 months and on the examination date

Height at 3, 6, 12, 18, 24 months and on the examination date

Gestational age at delivery

Vaginal birth or C-section

Weight of baby born

Length circumference after birth

Head circumference after birth

Any congenital anomalies detected in baby born

The Apgar score is determined by evaluating the newborn baby on five simple criteria on a scale from zero to two, then summing up the five values thus obtained. The resulting Apgar score ranges from zero to 10. The five criteria are summarized using words chosen to form a backronym (Appearance, Pulse, Grimace, Activity, Respiration).

Rate of Apgar score at 5 minute after birth <7

Admission to neonatal intensive care unit of baby

Number of admission days to NICU

Respiratory distress syndrome (RDS), diagnosed as the presence of tachypnoea >60/minute, sternal recession and expiratory grunting, need for supplemental oxygen, and a radiological picture of diffuse reticulogranular shadowing with an air bronchogram.

Periventricular haemorrhage II B or worse, will be diagnosed by repeated neonatal cranial ultrasound by the neonatologist according to the guidelines on neuro-imaging described by de Vries et al.

Necrotizing enterocolitis (NEC) will be diagnosed according to Bell.

Proven sepsis, will be diagnosed on the combination of clinical signs and positive blood cultures.

Composite of poor perinatal outcomes, defined as intraventricular haemorrhage, respiratory distress syndrome, necrotizing enterocolitis or neonatal sepsis.