Childhood Trauma in Schizophrenia: Exploration of Links Between Gene Expression, Cerebral Morphology and Symptomatology

Inclusion criteria

of patients :

• For women with reproductively active age period: suitable contraceptive method and negative pregnancy test
• Schizophrenia diagnosis (according to DSM 5)
• Regular follow-up care at hospital
• No change in antipsychotic medication (medication AND dosage) within at least six weeks
• Patient into remission : constant dosage, out-patient and meeting Andreassen criteria
• Who have given their informed consent before participating in the study.
• Physical examination without significant clinical physical anomaly
• No serious somatic pathology
• Affiliates or entitled to a social security scheme

Exclusion criteria

of patients :

• For women with reproductively active age period: no suitable contraceptive method (oral, hormonal, intramuscular, intrauterine device, or surgical)
• Pregnancy or breastfeeding
• Not meeting schizophrenic criteria according to DSM 5 or presenting resistant schizophrenic criteria according Kane criteria
• Presenting a serious somatic disorder or neurological (particularly Parkinson disease, epilepsy, tardive dyskinesia)
• Cardiovascular, hepatic or serious renal diseases
• Contraindication to MRI examination, particularly ocular or intracranial metallic foreign object,pacemaker, artificial heart valve, surgical clip
• Claustrophobia, significant tatoo in the high part of the body, IUD incompatible with MRI 3Tesla
• Alcohol or drug addiction, within the last year
• Recruited in other clinical trial or exclusion period from previous trial.
• Susceptibility to self-harm behaviour according to investigator

Inclusion criteria

of Related volunteers :

• Age, gender and socio-educational level similar to recruited patients
• Who have given their informed consent before participating in the study.
• First degree relative of schizophrenic patient diagnosed according DSM IV criteria
• No schizophrenia diagnosis according DSM IV criteria
• No psychiatric history and free of psychotropic drugs/treatment
• Physical examination without significant clinical anomaly
• Affiliates or entitled to a social security scheme

Exclusion criteria

of Related volunteers :

• For women with reproductively active age period: no suitable contraceptive method (oral, hormonal, intramuscular, intrauterine device, or surgical)
• Pregnancy or breastfeeding
• Presenting somatic, neurological or psychiatric disorder
• Alcohol or drug addiction, within the last year
• Recruited in other clinical trial or exclusion period from previous trial.
• Contraindication to MRI examination, particularly ocular or intracranial metallic foreign object, pacemaker, artificial heart valve, surgical clip
• Claustrophobia, significant tatoo in the high part of the body, IUD incompatible with MRI 3Tesla

Inclusion criteria

of Healthy volunteers :

• Age, gender and socio-educational level similar to recruited patients
• Who have given their informed consent before participating in the study.
• No schizophrenia diagnosis according DSM IV criteria
• No personal or family history of psychiatric disorders
• Free of psychotropic drugs/treatment
• Physical examination without significant clinical anomaly
• Affiliates or entitled to a social security scheme

Exclusion criteria

of Healthy volunteers :

Beside the absence of schizophrenia diagnosis, healthy volunteers should meet the same exclusion criteria as patients