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Completed

NCT Number: NCT02433275

CHildhood ASthma and Environment Research Study - CHASER Study

"CHildhood ASthma and Environment Research study - CHASER study" is an observational longitudinal study in outpatient clinic of Pediatric Allergology & Pulmonology (PAP) of Respiratory Disease Research Center (RDRC) within the Institute of Biomedicine and Molecular Immunology (IBIM) of the National Research Council (CNR) of Palermo (RDRC-IBIM CNR), Italy.

The first phase - transversal study will identify determinants of pediatric asthma control

The second phase - longitudinal study, in patients with persistent asthma, will be focused on:

* predictors for asthma exacerbations and loss of control * real life adherence to asthma therapy guidelines * phenotypic characterization through the collection of saliva samples * assessment of alterations and inflammatory changes in the nasal mucosa through nasal brushing * evaluation of the presence of 8-isoprostane, nicotine, cotinine and bisphenol-A through urine analysis.

Chaser Project is expected to improve the knowledge of pediatric asthma in patients with different level of control, identifying predictors for asthma exacerbations and loss of control.

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Key information

Conditions

Asthma Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

5 year–16 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Institute of Biomedicine and Molecular Immunology, IBIM

Palermo, 90146, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • age 5-16 years
  • asthma
  • not asthma

Exclusion criteria

  • chest deformity
  • active smoking

Treatment and study plan

Primary outcomes

  1. Asthma

    Time frame: 5 years

Secondary outcomes

  1. Measures from saliva samples

    Time frame: 5 years

  2. Measures from nasal brushing

    Time frame: 5 years

  3. Measures from urine samples

    Time frame: 5 years

Sponsors and collaborators

Lead sponsor

Stefania La Grutta, MD

Other

Registry information

Important dates

Study start
2011
Primary completion
2020
Study completion
2020
First posted
May 4, 2015
Registry last updated
Apr 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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