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OpenTrials
Active, Not Recruiting

NCT Number: NCT00961792

Chicago Social Drinking Project

This study attempts to elucidate the factors that contribute to escalation and maintenance of excessive ethanol drinking in young adults by:

1. Examining subjective and objective response differences to alcohol and other common substances in a sample of adults with varying consumption patterns. 2. Determining whether response to alcohol and other substances is predictive of future consumption patterns through longitudinal follow-up interviews. 3. Examining the relationship between responses to alcohol and other substances at baseline and re-examination testing to evaluate if consumption patterns moderate this relationship.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Alcoholism Alcohol-Related Disorders Chemically-Induced Disorders Mental Disorders Substance-Related Disorders

Age range

21 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Clinical Addictions Research Laboratory

Chicago, Illinois, 60637, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 21-65
  • Weigh between 110-210 lbs
  • Drink alcohol at least once weekly with weekly "binge" drinking episodes
  • Available to complete in-person screening and 2, 4 hour experimental sessions at the University of Chicago
  • Available by phone, mail, or Internet for follow-up interviews for at least 2 years following sessions

Exclusion criteria

  • Current or past major medical or psychiatric disorders including alcohol and substance dependence

Treatment and study plan

Ethanol

Drug

Beverage containing 0.8 g/kg ethanol, 0.4 g/kg ethanol

Other names: Kool-Aid, Splenda, Everclear

Placebo

Drug

Beverage containing 0.0 g/kg alcohol to act as placebo

diphenhydramine

Drug

Beverage containing dose equivalent to 1.5 standard doses of Diphenhydramine (Benadryl)

Other names: Benadryl

Caffeine

Drug

Beverage containing the equivalent of 1.5 times the participant's daily caffeine intake

Primary outcomes

  1. Subjective response to alcohol and other common substances utilizing mood questionnaires in adult drinkers

    Time frame: Measured during 5 timepoints at each experimental session: 1) Pre-drink baseline, 2) +30 minutes, 3) +60 minutes, 4) +120 minutes, and 5) +180 minutes following the initiation of beverage consumption

Secondary outcomes

  1. Substance Use Behavior Reported During Follow-Up Interviews

    Time frame: Measured at 3, 6, 9, 12, 15, 18, 21, 24, 36, 48, and 60 months following the final experimental session

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Collaborators

  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Registry information

Official study title

Individual Differences After Consumption of Alcohol and Other Common Substances and Long-Term Follow-Up of Social Drinking, Young Adults

Acronym: CSDP

Important dates

Study start
2004
Primary completion
2026
Study completion
2027
First posted
Aug 19, 2009
Registry last updated
Apr 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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