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Completed

NCT Number: NCT07124182

Chewing Gum During a Pap Smear

This study, which was conducted to determine the effects of chewing gum on anxiety and pain during Pap smear, found that chewing gum reduced pain but had no effect on anxiety.

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Key information

Age range

18 year–50 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Firat Universty

Elâzığ, Turkey, 23100, Turkey (Türkiye)

About this study

Cervical cancer is one of the most common malignancies in women aged 35-44. Cervical cancer screening methods include the Papanicolaou test (PAP) via cytopathology, and the Pap smear is widely used for early detection of cervical cancer. A Pap smear involves a speculum examination, direct visualization of the cervix, and collection of a sample from the cervix using a brush. ACOG recommends screening for women aged 30-65 with cervical cytology alone every 3 years, with high-risk HPV testing alone every 5 years, or with cytology and high-risk HPV testing (concurrent testing) every 5 years (ACOG).

Women often experience anxiety and pain during pelvic procedures. Anxiety is a distressing emotional state. Many women with increased anxiety are at risk of experiencing pain. An adrenergic response is activated between the physiological effects of anxiety and the perception of pain. It has been reported that the pap smear procedure, which is a pelvic procedure, is relatively short, and cognitive and behavioral interventions that distract the patient can be effective in reducing pain and anxiety. In addition, strategies for alleviating pain and anxiety include pharmacological and non-pharmacological interventions. Non-pharmacological methods are reported to be inexpensive and easy to implement, and have relatively few side effects. Various interventions, such as booklets, brochures, informative videos, education, and music, have been tested in the literature to reduce anxiety and pain levels. Neuropsychology confirms that chewing gum increases sustained attention. Chewing gum has a sustained effect on alertness and attention. Chewing gum can lower cortisol levels, reduce distractions, and increase cognitive focus. This can reduce overall stress and anxiety. Chewing gum is reported to be a cheap, well-tolerated, safe, and effective way to alleviate anxiety and stress . There are no direct studies in the literature on the use of gum during Pap smears. This study aimed to examine the effect of chewing gum during Pap smears.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women who are literate, can speak and understand Turkish, are not pregnant, are not in menopause, and have experienced sexuality

Exclusion criteria

  • women diagnosed with cervical cancer

Treatment and study plan

shewing gum

Other

Chewing gum is a cost-effective practice that can provide comfort to women. A Pap smear is an important test. Women experiencing pain, anxiety, or other symptoms may discourage testing. Chewing gum can reduce these sensitivities.

Primary outcomes

  1. Change in pain level during Pap smear procedure

    Time frame: Immediately after completion of the Pap smear procedure (within approximately 10 minutes)

    Change from baseline in self-reported pain score, measured using the Visual Analog Scale (VAS; 0-10), during and immediately after the Pap smear procedure

  2. Change in anxiety level during gynecological examination

    Time frame: Immediately after completion of the gynecological examination (within approximately 10 minutes)

    Change from baseline in self-reported anxiety score, measured using the State-Trait Anxiety Inventory (STAI; range 20-80), during and immediately after the gynecological examination

Sponsors and collaborators

Lead sponsor

Firat University

Other

Registry information

Official study title

Chewing Gum During a Pap Smear: A Randomized Controlled Clinical Trial

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Aug 15, 2025
Registry last updated
Aug 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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