Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT06950723

Chest Physical Therapy on Arterial Blood Gases for Neonates Post Hypoxic Ischemic Encephalopathy

Hypoxic-ischemic encephalopathy (HIE) is a dangerous illness that happens when a newborn's brain does not receive adequate oxygen and blood flow, which can result in serious effects such as cerebral palsy and epilepsy. Infant diagnosed with HIE required ventilator support and subsequently developed pneumonia. They experienced respiratory problems and feeding challenges. Chest Physical Therapy is the best modalities to clear chest and improve ventilation.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Conditions

Hypoxic Ischemic Encephalopathy of Newborn

Age range

1 day–10 day

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

The purpose of this study to investigate the effect of chest physical therapy on Arterial Blood Gases for neonates post hypoxic ischemic encephalopathy (HIE) in Neonatal intensive care unit.

Methods: Fifty neonates from both sexes, age from birth to 10 days, post HIE with chest problems were selected from neonatal intensive care unit (NICU) at Minia University hospital, Egypt. They were divided into two equal groups, control group (CG) received traditional medical treatment according to American Academy of Pediatrics (AAP) recommendations and study group (SG) received traditional medical treatment plus Chest Physical Therapy (CPT) modalities in the form of postural drainage, percussion and vibration. The sessions will apply once daily for 6 days/week, each session is about 30 minutes, according to the neonate tolerance till complete clinical cure and discharge from NICU.

the outcome will measure by Timing of Arterial blood gases improvement, Duration required for clinical improvement, Duration of Mechanical ventilation, Duration of Hospitalization.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Neonates with chest problems post Hypoxic-ischemic encephalopathy

Exclusion criteria

  • Neonates with chest problems due to other Causes except post Hypoxic-ischemic encephalopathy.
  • unstable medical status
  • Neonates with Post-operative s' respiratory problems due to any reasons.

Treatment and study plan

Chest Physical Therapy (CPT) modalities , Medical Treatment

Other

Chest Physical Therapy (CPT) modalities in the form of postural drainage, percussion and vibration.

Primary outcomes

  1. Timing of Arterial blood gases improvement

    Time frame: 3-14 days

    Time needed to improve Arterial blood gases due to CPT

  2. Timing required for clinical improvement

    Time frame: 3-14 days

    Time needed to improve clinical signs due to CPT

  3. Timing needed for Mechanical Ventilation

    Time frame: 3-7 days

    Time needed to Mechanical Ventilation support.

  4. Hospitalization time

    Time frame: 5-21 days

    All staying duration need for the neonates from admission till discharge from the hospital.

Study contacts

Contact information is provided by the study sponsor or research team.

Elsayed Mehrem, Associate Professor

CONTACT

[email protected]

+201006973334

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Efficacy of Chest Physical Therapy on Arterial Blood Gases for Neonates Post Hypoxic Ischemic Encephalopathy in Neonatal Intensive Care Unit: A Clinical Trial Study

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Apr 30, 2025
Registry last updated
Apr 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.