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OpenTrials
Completed

NCT Number: NCT03968471

Chemotherapy-induced Necrosis in Ewing Sarcoma

This is single institution cases series review of histological and clinical data

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Key information

Conditions

Ewing Sarcoma of Bone

Sex eligibility

All sexes

Study type

Observational

Primary location

Dept. of Pathology of IRCCS Istituto Ortopedico Rizzoli

Bologna, 40136, Italy

About this study

Investigators will retrieve from the database of the Rizzoli institute all the cases with a histological diagnosis of Ewing sarcoma from 01 Jan 1982 to 31 Dic 2012

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male and female patients surgically treated at Rizzoli Institute from 01 Jan 1982 to 31 Dic 2012
  • Patients with diagnosis of Ewing sarcoma of bone who have had neo-adjuvant chemotherapy
  • Diagnosis of Ewing sarcoma localized

Exclusion criteria

  • Metastatic disease at presentation
  • Soft tissue origin
  • Radiotherapy before surgery

Treatment and study plan

Scoring tool in Chemotherapy-induced necrosis in Ewing sarcoma

Behavioral

The aim of the present study is to evaluate which is the best scoring tool to determine the histological response to chemotherapy in localized Ewing sarcoma of bone.

The study will exam all the different systems to evaluate the histological necrosis after neo-adjuvant chemotherapy in all patients with localized Ewing sarcomas of bone surgically treated between 1982 and 2012.

Primary outcomes

  1. retrospective analysis of cases of Ewing sarcomas

    Time frame: at baseline (Day0)

    Investigators will exam the histological response to chemotherapy in localized Ewing sarcoma of bone and correlate it to clinical outcome.

Sponsors and collaborators

Lead sponsor

Istituto Ortopedico Rizzoli

Other

Registry information

Official study title

Chemotherapy-induced Necrosis in Ewing Sarcoma: Which is the Best Scoring Tool

Important dates

Study start
2019
Primary completion
2019
Study completion
2020
First posted
May 30, 2019
Registry last updated
Jan 22, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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