Chemoradiotherapy Following Immunotherapy Plus Chemotherapy for Locally-advanced Esophageal Squamous Cell Cancer (RICE)

Inclusion criteria

• Aged ≥ 18 years at the time of screening.
• Histologically confirmed squamous cell carcinoma;
• Locally-advanced ,medical inoperability, technical irresectability, or patient refusal to surgery;
• Eastern Cooperative Oncology Group (ECOG) performance status:0-2;
• Able to eat a semi-liquid diet;
• Less than 20% weight loss within 6 months;
• Adequate hepatic function, renal function, hematologic function and coagulation function;
• Documented informed consent.

Exclusion criteria

• Distant metastasis;
• Known malignancy diagnosed or require active treatment in the last 5 years, except for cancers that can be cured by surgery including cervical cancer in situ, basal or squamous cell skin cancer, breast ductal carcinoma in situ, localized prostate cancer;
• Prior thoracic irradiation, chemotherapy, or lobectomy
• Known diseases or conditions that are contraindicated for radiotherapy or surgery;
• Allergy to the research medications;
• Pregnant women or women preparing for pregnancy;
• Diagnosis of autoimmune disease or history of chronic autoimmune disease
• Absence of informed consent because of psychological, family, social and other factors;
• Patients with comorbidities (chronic pulmonary disease, poorly controlled hypertension, unstable angina, myocardial infarction within 6 months, unstable mental disorders requiring therapy).