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Completed

NCT Number: NCT07148687

ChatGPT and DeepSeek-Assisted Rehabilitation in Subacromial Pain

This study aims to evaluate the effects of rehabilitation programs supported by artificial intelligence-based large language models (LLMs), specifically ChatGPT and DeepSeek, in individuals with subacromial pain syndrome (SAPS). Participants will be randomly assigned to one of three groups: standard physiotherapy, standard physiotherapy plus ChatGPT-guided exercises, and standard physiotherapy plus DeepSeek-guided exercises. Outcomes including pain, disability, quality of life, muscle strength, and joint range of motion will be assessed before and after a 6-week intervention. The results will help determine whether AI-generated exercise recommendations can enhance clinical outcomes when combined with conventional physiotherapy.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kırşehir Ahi Evran University Training and Research Hospital, Physical Medicine and Rehabilitation Department

Kırşehir, Merkez, 40100, Turkey (Türkiye)

About this study

This completed randomized controlled trial investigated the clinical effects of integrating AI-generated exercise recommendations into conventional physiotherapy for individuals with subacromial pain syndrome (SAPS). A total of 82 individuals were assessed for eligibility; 7 were excluded for not meeting inclusion criteria. Seventy-five participants provided consent and were randomized in a 1:1:1 ratio to 3 groups (n=25 each): (1) conventional physiotherapy plus a conventional exercise program, (2) conventional physiotherapy plus ChatGPT-guided exercises, and (3) conventional physiotherapy plus DeepSeek-guided exercises. The allocation sequence was generated using simple computer-based randomization by an independent staff member and was revealed after completion of baseline assessments. Interventions were delivered over 6 weeks (3 supervised sessions/week). Six participants discontinued the intervention due to scheduling conflicts (2 per group). Sixty-nine participants completed the 6-week intervention and were included in the final analysis (n=23 per group). The primary outcome was shoulder pain and disability (Shoulder Pain and Disability Index, SPADI), assessed at baseline and 6 weeks. Secondary outcomes included pain intensity (Numeric Pain Rating Scale, NPRS), health-related quality of life (Short Form-12, SF-12), upper limb function (Disabilities of the Arm, Shoulder and Hand, Quick DASH), range of motion, isometric strength, kinesiophobia, catastrophizing, emotional status, and disease-specific quality of life.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Being between the ages of 18 and 65
  • Having been diagnosed with Subacromial Pain Syndrome (SAPS) for at least four weeks, diagnosed through clinical and physical examination
  • Actively maintaining shoulder range of motion
  • Being cognitively and physically capable of participating in an exercise program
  • Agreeing to participate voluntarily in the research process and providing written consent

Exclusion criteria

  • Presence of other shoulder pathologies such as rotator cuff tear, frozen shoulder, glenohumeral instability, or labrum tear
  • Presence of conditions included in the differential diagnosis such as cervical radiculopathy, neurological disorders, rheumatological diseases, or fibromyalgia
  • History of shoulder surgery within the last 6 months
  • Pregnancy
  • History of systemic or neuromuscular disease
  • Refusal to consent to voluntary participation

Treatment and study plan

Conventional Exercise Program

Behavioral

Exercise protocol targeting subacromial pain syndrome, including shoulder mobility, strengthening, and posture correction exercises based on established clinical guidelines.

ChatGPT-Guided Rehabilitation

Behavioral

AI-generated exercise recommendations from ChatGPT-4 tailored to the patient's profile and applied under physiotherapist supervision.

DeepSeek-Guided Rehabilitation

Behavioral

Personalized rehabilitation exercises generated by DeepSeek-R1 and implemented under physiotherapist guidance.

Primary outcomes

  1. Change in Disability (Shoulder Pain and Disability Index, SPADI)

    Time frame: Baseline and after 6 weeks of intervention

    Disability related to shoulder pain will be measured.Shoulder Pain and Disability Index (0-100; higher scores indicate worse disability).

Secondary outcomes

  1. Change in upper extremity function (Quick DASH)

    Time frame: Baseline and after 6 weeks

    Functional status of the arm, shoulder, and hand will be assessed using the Disabilities of the Arm, Shoulder and Hand (Quick DASH) questionnaire. Higher scores indicate greater disability.

  2. Change in shoulder range of motion (ROM)

    Time frame: Baseline and after 6 weeks

    Active range of motion in shoulder flexion, extension, abduction, internal and external rotation will be measured using a standard manual goniometer.

  3. Change in Quality of Life (Short Form-12, SF-12)

    Time frame: Baseline and after 6 weeks of intervention

    Health-related quality of life will be evaluated.Short Form-12 (Physical Component 12-48; Mental Component 12-48; higher scores indicate better quality of life).

  4. Change in Pain Intensity (Numeric Pain Rating Scale, NPRS)

    Time frame: Baseline and after 6 weeks of intervention

    Pain intensity will be assessed using the Numeric Pain Rating Scale (NPRS) at rest, during activity, and at night. Numeric Pain Rating Scale (0-10; higher scores indicate worse pain).

  5. Change in shoulder and elbow muscle strength (K-Force)

    Time frame: Baseline and after 6 weeks

    Isometric muscle strength of shoulder and elbow flexion, extension, and rotation will be assessed using the Kinvent K-Force digital dynamometer. Values will be recorded in Newtons.

  6. Change in Kinesiophobia (Tampa Scale for Kinesiophobia, TSK)

    Time frame: Baseline and after 6 weeks

    Kinesiophobia will be measured using the Tampa Scale for Kinesiophobia (TSK). Tampa Scale for Kinesiophobia (17-68; higher scores indicate greater fear of movement).

  7. Change in shoulder function (American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form, ASES)

    Time frame: Baseline and after 6 weeks

    Shoulder function will be evaluated using the American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form (ASES). ASES (0-100; higher scores indicate better shoulder function).

  8. Change in Pain Catastrophizing (Pain Catastrophizing Scale, PCS)

    Time frame: Baseline and after 6 weeks of intervention

    Pain catastrophizing will be assessed.Pain Catastrophizing Scale (0-52; higher scores indicate worse catastrophizing).

  9. Change in Emotional Status (Hospital Anxiety and Depression Scale, HADS)

    Time frame: Baseline and after 6 weeks of intervention

    Anxiety and depression will be evaluated.Hospital Anxiety and Depression Scale (0-21 for Anxiety subscale, 0-21 for Depression subscale; higher scores indicate worse symptoms).

  10. Change in disease-specific quality of life (Western Ontario Rotator Cuff Index, WORC)

    Time frame: Baseline and after 6 weeks of intervention

    Disease-specific quality of life in patients with shoulder pathology will be measured.WORC (0-2100; higher scores indicate worse symptoms / lower quality of life).

Sponsors and collaborators

Lead sponsor

Kirsehir Ahi Evran Universitesi

Other

Registry information

Official study title

Effect of ChatGPT and DeepSeek-Guided Rehabilitation on Clinical Outcomes in Individuals With Subacromial Pain Syndrome

Acronym: LLM-RehabSP

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Aug 29, 2025
Registry last updated
Feb 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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