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OpenTrials
Completed

NCT Number: NCT03609333

Characterizing the cerebrovAscular Physiology of Optimal Mean Arterial Pressure Targeted Resuscitation

Hypoxic ischemic brain injury is a devastating illness that occurs after cardiac arrest (the heart stopping) and can yield irreversible brain damage, often leading to death. The mainstay in therapy is to optimize the delivery of oxygen to the brain to help it recover. In patients with traumatic brain injury (similar to HIBI), the investigators are able to optimize oxygen delivery to the brain with the use of wires placed into the brain that sense the pressure and oxygen in the skull to find the ideal blood pressure for each individual patient. This strategy is associated with improved outcomes. The investigators are conducting a prospective study investigating whether the perfusion within proximity to the optimal MAP is associated with improved brain oxygenation and blood flow .

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Key information

Conditions

Cardiac Arrest Cardiovascular Diseases Heart Arrest Heart Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Vancouver General Hospital

Vancouver, British Columbia, V5Z 1M9, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Confirmed cardiac arrest with return of spontaneous circulation > 10 minutes
  • post resuscitation GCS < 9

Exclusion criteria

  • concurrent coagulopathy
  • prior history of TBI, intracranial hemorrhage, subarachnoid hemorrhage
  • anticipated cardiac catheterization within next 7 days
  • anticipated or current use of anticoagulants or anit-platelets

Treatment and study plan

Multimodal neuromonitoring

Device

Application of multimodal neuromonitoring

Other names: Targeted optimal MAP resuscitation

Primary outcomes

  1. Cerberal blood flow

    Time frame: 12 hours

    mls/100g/min

Sponsors and collaborators

Lead sponsor

University of British Columbia

Other

Registry information

Official study title

Characterizing the cerebrovAscular Physiology of Optimal Mean Arterial Pressure Targeted Resuscitation in Hypoxic Ischemic Brain Injury After Cardiac Arrest

Acronym: CAMPHIBIII

Important dates

Study start
2016
Primary completion
2020
Study completion
2020
First posted
Aug 1, 2018
Registry last updated
Nov 3, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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