Characterization of the Microbiome in Peritoneum, Jejunum, Rectum and Stool

Characterization of the human microbiome in the jejunum and comparison to the microbiome in the rectum and stool in order to see how the microbial communities change within the intestines.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Obesity Body Weight Chronic Disease Chronic Pancreatitis Diabetes Mellitus Digestive System Diseases Disease Attributes Endocrine System Diseases Fatty Liver Fatty Liver, Nonalcoholic Glucose Metabolism Disorders Leaky Gut Syndrome Liver Diseases Metabolic Diseases Non-alcoholic Fatty Liver Disease Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pancreatic Diseases Pancreatitis Pancreatitis, Chronic Pathologic Processes Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland,

Homburg/Saar, D-66421, Germany

About this study

Subjects to undergo surgery with opening of the jejunum will be sampled with sterile swabs from peritoneum and the inside of the jejunum. A swab will also be taken from the rectum.

The peritoneum is regarded as a sterile place until today. We try to either verify this, we also could find a scientific base for theories like leaky gut or other forms of bacterial migration through the intestinal wall.

Many of these patients undergo bariatric surgery. Many of them do have a dramatic change in glucose metabolism immediate after surgery. Therefore stool swabs will be taken before and 5 days after surgery.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

abdominal surgery containing opening of jejunum
singing of consent

Exclusion criteria

inflammative condition (appendicitis, pancreatitis, Crohn, Colitis ulcerous, cholecystitis and similar)

Treatment and study plan

Microbial Swab

Diagnostic Test

Swabs will be taken from peritoneum and jejunum (intraoperatively), rectum, and stool

Primary outcomes

Characterization of microbiome

Time frame: intra-operative

Previously uncharacterized sites: jejunum, peritoneum

Sponsors and collaborators

Lead sponsor

Universität des Saarlandes

Other

Registry information

Official study title

Characterization and Comparison of the Human Microbiome in Peritoneum, Jejunum, Rectum and Stool

Acronym: METABIOM

Important dates

Study start: 2019
Primary completion: 2023
Study completion: 2024
First posted: Aug 26, 2019
Registry last updated: May 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed