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OpenTrials
Completed

NCT Number: NCT05046587

Characterization of Suicidal Depression

Antidepressants are widely used to prevent suicidal risk. However, even though the use of antidepressants has been associated with a 40-60% decrease in suicidal risk, they do not seem to be sufficient and appropriate. Indeed recent studies have shown that patients with a history of suicide attempt and/or with current suicidal ideation (SI) respond less well to antidepressant treatments. This suggests that patients with depression with SI may be different from those with depression without SI, thus requiring specific treatments for both SI reduction and depressive remission. In other words, suicidal depression may be a specific subtype of depression.

The study aims to characterize the clinical phenotype of patients with suicidal depression vs. those without suicidal depression, and to assess the occurrence of suicidal events at one year in patients with suicidal depression vs. without suicidal depression.

All data having already been collected during the particpation of patients in various clinical research studies of the department

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Key information

Conditions

Depression Behavior Behavioral Symptoms Self-Injurious Behavior Suicidal Ideation Suicide

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Uhmontpellier

Montpellier, 34295, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Over 18 years old
  • Hospitalization in the Department of Emergency Psychiatry and Acute Care (Montpellier University Hospital) between 2012 and 2019
  • Having being enrolled in one the department's clinical studies between 2012 and 2019
  • Moderate to severe characterized depressive episode according to DSM-5 diagnostic criteria (severity assessed with BDI, IDSC-30 and QIDS)

Exclusion criteria

  • Protection by law (guardianship or curatorship)
  • Deprivation of liberty (by judicial or administrative decision)
  • Bipolar disorder

Treatment and study plan

Primary outcomes

  1. characterization of the patient clinical phenotype

    Time frame: day 1

    characterization of the patient clinical phenotype

Secondary outcomes

  1. Suicidal events at one year

    Time frame: 1 year

    Occurrence of suicidal events (actual, interrupted and aborted or self-aborted suicide attempts) assessed with C-SSRS suicidal behaviour subscale (4 yes/no questions)

  2. Hospitalization for suicidal ideation

    Time frame: 1 year

    Occurrence of hospitalization for suicidal ideation, based on the patient medical record

  3. Suicidal events at one year

    Time frame: 1 year

    Occurrence of suicidal events (actual, interrupted and aborted or self-aborted suicide attempts) based on the patient medical records

Sponsors and collaborators

Lead sponsor

University Hospital, Montpellier

Other

Registry information

Official study title

Characterization of Suicidal Depression Within a Large Cohort of Inpatients: a One-year Prospective Study.

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Sep 16, 2021
Registry last updated
Nov 15, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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