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OpenTrials
Completed

NCT Number: NCT04448782

Characterization of Reverse Triggering and Other Asynchronies in COVID-19 Patients Under Invasive Mechanical Ventilation

Prospective observational trial in patients admitted to ICU diagnosed with COVID-19 requiring invasive mechanical ventilation. Characterization of Reverse Triggering asynchrony during the first 5 days of invasive mechanical ventilation and other asynchronies, and its correlation with different outcomes.

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Key information

Conditions

Mechanical Ventilation Complication

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Candelaria de Haro

Sabadell, Barcelona, 08208, Spain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients under invasive mechanical ventilation more than 24 hours and with a minimum of 48 hours of respiratory signals registered from the ventilator
  • Diagnosis of COVID-19

Exclusion criteria

  • less than 48 hours of data,
  • age < 18 years
  • admitted from other centers under invasive mechanical ventilation.

Treatment and study plan

Asynchronies detection

Diagnostic Test

Asycnhronies detection

Primary outcomes

  1. Incidence and pattern of presentation of Reverse triggering in COVID-19 patients under invasive mechanical ventilation

    Time frame: during the 5 first days of invasive mechanical ventilation

    To analyze the incidence of Reverse Triggering in the initial phases of invasive mechanical ventilation in COVID-19 patients

Secondary outcomes

  1. Incidence of Reverse Triggering related to the level of sedation in COVID-19 patients under invasive mechanical ventilation

    Time frame: From the day of mechanical ventilation initation up to 5 days or the last day of mechanical ventilation

    To correlate the presence of Reverse Triggering with the level of sedation and use of neuromuscular blockers

  2. Reverse triggering and secondary asynchronies in COVID-19 patients under invasive mechanical ventilation

    Time frame: From the day of mechanical ventilation initiation up to 5 days

    To analyze the incidence of breath stacking and ineffective efforts secondary to RT.

  3. Incidence and pattern of presentation of asynchronies in COVID-19 patients under invasive mechanical ventilation

    Time frame: Each day from the day of mechanical ventilation initiation until the day of mechanical ventilation withdrawal or up to 28 days

    To analyze the incidence of RT, ineffective efforts and double triggering throughout the period of invasive mechanical ventilation

  4. Influence of asynchronies in different outcomes in in COVID-19 patients under invasive mechanical ventilation

    Time frame: Each day from the day of mechanical ventilation initiation until the end of invasive mechanical ventilation, ICU discharge and hospital discharge or up to 28 days

    To correlate the presence of asycnhronies and its type with duration of invasive mechanical ventilation, ICU length of stay and survival

Sponsors and collaborators

Lead sponsor

Corporacion Parc Tauli

Other

Registry information

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Jun 26, 2020
Registry last updated
Jul 14, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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