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NCT Number: NCT02614911

Characterization of Phenotype and Genotype of Early Onset Enteropathies

This study has been set up in order to characterize phenotypes and genotypes of patients with early onset enteropathies.

In that goal, Investigators will collect biological samples (mainly blood) of patients suffering from early onset enteropathies and their healthy relatives.

Recruiting

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Key information

Conditions

Inflammatory Bowel Disease Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Inflammatory Bowel Diseases Intestinal Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre Hospitalier Pellegrin-Enfants, Bordeaux, France

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About this study

This study specifically aims at the genetic analysis of early onset enteropathies with the goal in mind to delineate human pathways necessary to maintain intestinal homeostasis despite the considerable density of microbes colonizing the distal part of the human intestine.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Main Inclusion Criteria:

  • Severe chronic enteropathy
  • Patients developing their first symptoms within the first 6 years of life and, in priority within the first two years of life, or patients with a disease of later onset, in case of a familial history suggestive of inherited mutations notably in families comprising several affected members
  • OR : Be a patient's relative, even if presenting with enteropathy of later onset.

Main Exclusion Criteria:

  • Subject having participated to any therapeutical clinical study in the 30 days preceding the inclusion in this study,

Treatment and study plan

Biological sampling

Other

Biological sampling including blood, feces, biopsies...

Primary outcomes

  1. Increasing the current rate (20%) of genetic characterization of early onset entheropathies

    Time frame: 40 years

    Currently, around 20% of early onset entheropathies are genetically characterized. Investigators want to increase this rate via this research protocol.

    Our long term objective is to characterize phenotypes and genotypes of patients with early onset enteropathies.

Study contacts

Contact information is provided by the study sponsor or research team.

Fabienne Charbit-Henrion

CONTACT

[email protected]

+33 1 42 75 42 45

Nadine Cerf-Bensussan

CONTACT

[email protected]

+ 33 1 42 75 42 88

Sponsors and collaborators

Lead sponsor

Imagine Institute

Other

Registry information

Official study title

Host-Microbiota Interactions Across the Gut Immune System: Characterization of Phenotype and Genotype of Early Onset Enteropathies

Acronym: IMMUNOBIOTA

Important dates

Study start
2014
Primary completion
2054
Study completion
2054
First posted
Nov 25, 2015
Registry last updated
Apr 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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