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NCT Number: NCT06070558

ChAracterization of Normal and Pathological moRphological Variations of the TEMporomandibular Joint by Real-time magnetIc reSonance Imaging

The Real Time MRI Rapid Flash sequence is particularly interesting for the study of moving organs and joints.

This sequence will make it possible to characterize normal and pathological temporomandibular joint movements by MRI.

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Key information

Conditions

Healthy Craniomandibular Disorders Jaw Diseases Joint Diseases Mandibular Diseases Muscular Diseases Musculoskeletal Diseases Stomatognathic Diseases Temporomandibular Joint Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHRU de Nancy

Nancy, 54000, France

Location status: Recruiting

Location contact

Guillaume DROUOT, PhD

CONTACT

[email protected]

+33383157666 ext. +33

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult: age ≥ 18 years old;
  • Person with the capacity to understand the instructions given;
  • Person affiliated to a social security scheme or beneficiary of such a scheme;
  • Person having received complete information on the organization of the Clinical Investigation and having signed informed consent.

Exclusion criteria

  • Person with large-scale metallic dental reconstructions;
  • Edentulism more than 5 teeth;
  • Claustrophobia;
  • Contraindication to performing an MRI examination
  • Persons referred to in Articles 64, 65 and 66 of European Regulation 2017/745 on Medical Devices (RDM) and in L. 1121-5 to L1121-8 of the French Public Health Code

Treatment and study plan

MRI with Real Time MRI Rapid Flash sequence

Device

MRI examination of temporomandibular joint with Real Time MRI Rapid Flash sequence

Primary outcomes

  1. Curve representing the difference between displacement of condyles during Temporo Mandibular Joint (TMJ) movements in healthy subjects and in subjects with known Temporo Mandibular Disorder (TMD).

    Time frame: Baseline (day 0)

Secondary outcomes

  1. Curve representing the displacement of the articular discs during TMJ movements

    Time frame: Baseline (day 0)

  2. Curve representing the difference between displacement of joint discs during TMJ movements in healthy subjects and in subjects with known TMD

    Time frame: Baseline (day 0)

  3. Characterization of the volume in mm3 of the main masticatory muscles during movement by MRI in healthy and pathological subjects.

    Time frame: Baseline (day 0)

Study contacts

Contact information is provided by the study sponsor or research team.

Gabriela Hossu, PhD

CONTACT

0033 3 83 15 50 96

Pedro Augusto GONDIM TEIXEIRA, MD, PhD

CONTACT

[email protected]

0033 3 83 85 21 61

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Acronym: ARTEMIS

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Oct 6, 2023
Registry last updated
Jun 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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