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Completed

NCT Number: NCT04253730

Characterization of Corticospinal Excitability During Progressive Skin Cooling

This study characterizes the changes in corticospinal excitability that accompany basic cold stress via skin cooling that result in reduced skin or core temperature and shivering.

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Key information

Conditions

Hypothermia Due to Cold Environment

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

211 Max Bell Centre, University of Manitoba

Winnipeg, Manitoba, R3T 2N2, Canada

About this study

Cold stress is known to impair both fine and gross motor movement. Reductions in performance may have life threatening consequences in survival situations where maintenance of muscle control is necessary. Much of the effects cooling has on muscle performance is directly due to its effects on muscle tissue itself, whereas less is known about the effects on the central nervous system. Therefore, the purpose of the study was to characterize corticospinal excitability that accompanies basic cold stress via progressive skin cooling, resulting in reductions in skin (Tsk) or core (Tco) temperature and shivering.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adult
  • Right Handed
  • Pass Magnetic Stimulation Safety Checklist
  • Pass Medical Screening Questionnaire

Exclusion criteria

  • Left Handed
  • Any adverse responses to cold exposure (Raynaud's Syndrome)
  • Cardiorespiratory Disease

Treatment and study plan

cold stress

Other

60-90 mins of cooling via a liquid perfused suit circulating ~4-10°C liquid.

Primary outcomes

  1. Change in Corticospinal Excitability

    Time frame: at 0, 20, 40, 60 and 90 minutes

    Motor Evoked Potentials (MEP) as a percentage of the maximal compound muscle action potential (Mmax) measured via MEG at the Biceps Brachii will serve as the indices of Corticospinal excitbaility

Secondary outcomes

  1. Change in Spinal Excitability

    Time frame: at 0, 20, 40, 60 and 90 minutes

    Cervicomedullary Motor Evoked Potentials (CMEP) as a percentage of the maximal compound muscle action potential (Mmax) measured via MEG at the Biceps Brachii will serve as the indices of spinal excitability

  2. Change in Skin Temperature

    Time frame: at 0, 20, 40, 60 and 90 minutes

    Mean skin temperature of 7 sites

  3. Change in Core Temperature

    Time frame: at 0, 20, 40, 60 and 90 minutes

    Esophageal temperature is the most accurate method representing the temperature of the heart.

  4. Change in Metabolic Heat Production

    Time frame: at 0, 20, 40, 60 and 90 minutes

    Metabolic heat production serves as an objective way to quantify shivering thermogenesis.

Other outcomes

  1. Change in Peripheral nerve excitability

    Time frame: at 0, 20, 40, 60 and 90 minutes

    Excitability of the peripheral nerve measured via EMG at the biceps brachia ( the maximal compound motor action potential (Mmax).

  2. Change in Maximal Voluntary Contraction of Elbow Flexors

    Time frame: at 0, 20, 40, 60 and 90 minutes

    Maximal Isometric Force of elbow flexors measured in kg of force

Sponsors and collaborators

Lead sponsor

University of Manitoba

Other

Registry information

Important dates

Study start
2019
Primary completion
2022
Study completion
2022
First posted
Feb 5, 2020
Registry last updated
Dec 6, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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