NCT Number: NCT04950309
Background:
Brain activity produces magnetic fields. These fields can be measured outside the head. Existing technology, called MEG, measures these fields. Researchers are testing a new type of magnetic field sensor called OPM. They hope it can help pinpoint with very high accuracy where brain activity is generated.
Objective:
To develop and test a new type of sensor for measuring the magnetic fields produced by brain activity.
Eligibility:
Healthy people ages 18-65 who had a magnetic resonance imaging (MRI) scan under protocol 17-M-0181.
Design:
Participants may be asked to complete sessions on both the traditional MEG instrument and the OPM array.
For the MEG, 3 small coils will be placed on the participant s face with tape. Their head will be positioned inside the MEG device.
For the OPM, sensors are housed in a 3d printed array. The sensors will be attached to a cap placed on the participant s head.
For both scans, participants will be seated in a chair inside a magnetically shielded room. They may complete several tasks. In one task, plastic cells will be placed on their fingers. Puffs of air will be sent to these cells, which will stimulate the sense of touch. Other tasks may include the following stimuli: visual (such as checkerboards), auditory (such as beeps and tones), or language (words and letters).
Researchers may also obtain recordings while they stimulate the nerve in the participant s forearm using electrical current in small electrodes.
Participation is expected to last for 1 day. Additional optional scans may be offered for up to 1 year....
Interested in participating?
Request Info18 year–65 year
All sexes
Interventional
Not applicable
Bethesda, Maryland, 20892, United States
Location status: Recruiting
For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)
CONTACT
800-411-1222 ext. TTY8664111010
Study Description:
This protocol is a technical development protocol to characterize an optically pumped magnetometer (OPM) array used for measuring magnetic brain signals. We hypothesize that with our OPM arrays, we can achieve similar or better spatial resolution to that of a conventional MEG system.
Objectives:
Primary Objective 1: To fully characterize the performance of an OPM MEG array.
Primary Objective 2: To demonstrate that the OPM system can produce somatotopic maps accurately differentiating receptive fields of each finger. If successful, we will additionally determine if the system can differentiate receptive fields of each phalanx.
Endpoints:
Primary Endpoint: OPM array characterization parameters including signal to noise, sensitivity, bandwidth, and spatial
resolution, and comparison to similar parameters acquired on a standard SQID system.
Secondary Endpoint: Somatotopic representations of the digits of the hand
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
In order to be eligible to participate in this study, an individual must meet all of the following criteria:
Exclusion criteria
An individual who meets any of the following criteria will be excluded from participation in this study:
MEG recordings acquired on a standard whole brain SQUID MEG system. Stimuli will be used, including auditory, visual, or somatosensory stimuli. Language stimuli and median nerve stimulation may also be used.
MEG recordings acquired on an investigational OPM MEG system. Stimuli will be used, including auditory, visual, or somatosensory stimuli. Language stimuli and median nerve stimulation may also be used.
Time frame: throughout protocol
At each phase of array construction characterization parameters including signal to noise, sensitivity, bandwidth, and spatial resolution will be measured.
Time frame: throughout protocol
Somatotopic representations of the digits of the hand, potentially differentiating the individual phalanx of each finger.
Contact information is provided by the study sponsor or research team.
Allison C Nugent, Ph.D.
CONTACT
Anna M Namyst
CONTACT
National Institute of Mental Health (NIMH)
Nih
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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