Characterization and Recognition of Genetic Diseases by Photography

There are around 8,000 rare diseases and new ones are described every month in the scientific literature. They affect a limited number of patients. Nearly 80% of these diseases have a genetic origin and 30 to 40% of them are associated with dysmorphia. The latter can be suspected by evaluating the morphological characteristics of the patient. This medical skill, called dysmorphology, which allows a diagnosis to be made by evaluating the morphological characteristics of a patient, is based on experience. Diagnosis is often easy for relatively common diseases, but more difficult for rarer pathologies affecting few patients and often described in a single ethnicity and age of life.

The study aims to create a dataset specific to the application of methods from artificial intelligence. Extending the methodologies described to profile and extremity photographs will allow better recognition and description of dysmorphia.

This will allow to make diagnostic suggestions by comparison with the database. The Data Science team has already explored the notion of phenotypic similarity of patients.

Jean Feydy is a mathematician expert in image analysis and will ensure the scientific robustness of the study methods.

This project will conclude with the establishment of a diagnostic aid tool, integrating research results for doctors with a particular interest in developmental anomalies and intellectual disability.

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Key information

Conditions

Dysmorphology Disease Attributes Orphan Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Rare Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Necker enfants malades Hospital

Paris, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

The patient inclusion criteria are:

Patients having a medical genetics, maxillofacial surgery, or craniofacial surgery consultation as part of the management of a rare disease (in France, disease affecting less than 30,000 people) associated with dysmorphia at the level of the head or neck (area from the vertex to the clavicles): hypotelorism, hypertelorism, exophthalmos, brachycephaly, anterior plagiocephaly, micrognathia, microretrognathia, prognathia, low ear, oblique eyelid fissures above, oblique eyelid fissures below, narrow eyelid fissures , small mouth, anteverted nostrils, short nose, broad nose tip, broad nose bridge, prominent nose bridge.
Patients with a confirmed diagnosis of one of the following pathologies: Noonan, 22q11.2 deletion, Crouzon, Kabuki, Pitt Hopkins, Mowat Wilson, Cornelia de Lange, Treacher-Collins, Goldenhar or by Silver-Russel
Patients for whom photographs of the face and/or hands are taken as part of their treatment

The inclusion criteria for control subjects are:

Patients having a maxillofacial surgery consultation, as part of the management of a disease other than a rare disease associated with dysmorphia in the head or neck: acute pathology (wound) or chronic (gynecomastia).
Patients for whom photographs of the face and/or hands are taken as part of their treatment

The criteria for non-inclusion of patients are:

Patients who have undergone facial or skull surgery before the first photo was taken.
Person subject to a judicial safeguard measure.

The criteria for non-inclusion of control subjects are:

Pathologies affecting facial symmetry (dental cellulitis, displaced fractures).
Patient followed for dysmorphic syndrome or in whom dysmorphic syndrome has been suspected
Person subject to a judicial safeguard measure.

Treatment and study plan

Clinical Data reuse

Other

Clinical Data reuse

Primary outcomes

Relationship between phenotypic characteristics and genotype in rare pathologies associated with dysmorphia

Time frame: through study completion, an average of 1 year

Relationship between phenotypic characteristics (based on photographs landmarks) of the face and hand from rare pathologies associated with dysmorphia and genotype.

Secondary outcomes

Creation of a database of landmark photographs taken as part of care and including all patients seen in consultation

Time frame: through study completion, an average of 1 year

Creation of a database of landmark photographs taken as part of care and including all patients seen in consultation
Training an algorithm using collected data for diagnostic purposes

Time frame: through study completion, an average of 1 year

Training an algorithm using collected data to develop a dysmorphological diagnosis aid tool which could be particularly useful in situations of uncommon diseases where the clinician has not yet acquired the necessary expertise to make a diagnosis.

Sponsors and collaborators

Lead sponsor

Imagine Institute

Other

Registry information

Acronym: AIDY

Important dates

Study start: 2022
Primary completion: 2024
Study completion: 2024
First posted: Jan 25, 2024
Registry last updated: Jan 25, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed