Characterization and Differential Diagnosis of Postneurosurgical Meningitis

Meningitis is a rare complication following neurosurgical procedures and is associated with high morbidity and mortality. The aim of this study is to describe the clinical characteristics and microbiological characteristics in patients who develope meningitis following neurosurgical operations, and investigate the useful tips for the differential diagnosis of postneurosurgical meningitis.

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Key information

Conditions

Neurosurgery Infections Meningitis Nervous System Diseases Neuroinflammatory Diseases

Age range

16 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Asan Medical Center

Seoul, 138-736, South Korea

About this study

Besides description of characteristics of patients with postneurosurgical patients, we also will investigate the usefulness of prolonged cerebrospinal fluid (CSF) culture, and profiles of blood and CSF inflammatory markers for the differential diagnosis of meningitis. CSF culture will be extended upto 2 weeks. Serum procalcitonin and C-reactive protein, CSF adenosine deaminase levels will be monitored and analyzed for the differential diagnosis of meningitis.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Cerebrospinal fluid corrected WBC >6/mm^3 and/or fever (> 38℃) and/or neck stiffness

Exclusion criteria

Patients already treated more than 48 hours for meningitis before cerebrospinal fluid examination

Treatment and study plan

Primary outcomes

Development of meningitis

Time frame: within 4 weeks after neurosurgical operation

Secondary outcomes

All-cause mortality

Time frame: within 4 weeks after the diagnosis of meningitis

Sponsors and collaborators

Lead sponsor

Asan Medical Center

Other

Registry information

Official study title

Clinical Features, Microbiological Characteristics, and Differential Diagnosis of Postneurosurgical Meningitis

Important dates

Study start: 2010
Primary completion: 2013
Study completion: 2013
First posted: May 13, 2010
Registry last updated: Oct 1, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed