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NCT Number: NCT07014592

Characterization and Analysis of Evoked Cortical Responses in Participants With Medication-intractable Epilepsy

The goal of this project is to study how the brain reacts to a small electrical signal. Researchers will be using a novel combination of recording electrodes. The researchers will measure the brain response from these electrodes.

Recruiting

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Key information

Conditions

Intractable Epilepsy Brain Diseases Central Nervous System Diseases Drug Resistant Epilepsy Epilepsy Nervous System Diseases

Age range

22 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Michigan

Ann Arbor, Michigan, 48109, United States

Location status: Recruiting

Location contact

Matthew Willsey, MD, PhD

PRINCIPAL_INVESTIGATOR

Ron Ball

CONTACT

[email protected]

734-936-7010

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with medication intractable epilepsy who are recommended to undergo brain surgery to remove a "seizure" focus
  • Can provide informed consent for the study and willing to participate

Exclusion criteria

  • Presence of a permanent electronic implant
  • Any chronic medical conditions that prevent safe placement of electrodes

Treatment and study plan

stimulating probes and electrodes

Device

Subdural electrodes and/or ball tip probes will be used intraoperatively to provide electrical stimulation to the brain.

Primary outcomes

  1. Characterization of time-frequency data

    Time frame: During a 20 minute research phase of a clinically indicated surgery

    From recording electrodes

  2. Characterization of local field responses (LFPs)

    Time frame: During a 20 minute research phase of a clinically indicated surgery

    From recording electrodes

Study contacts

Contact information is provided by the study sponsor or research team.

Ron Ball

CONTACT

[email protected]

734 936-7010

Sponsors and collaborators

Lead sponsor

University of Michigan

Other

Registry information

Important dates

Study start
2025
Primary completion
2028
Study completion
2028
First posted
Jun 11, 2025
Registry last updated
Jun 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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