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OpenTrials
Completed

NCT Number: NCT06090773

Characteristics of Renal Blood Flow in AKI Patients in ICU and Its Clinical Significance

To study the changes in the renal artery and renal vein with renal cortical and medullary microcirculatory blood flow in patients with sepsis; to study the relationship between renal arteriolar and renal vein with renal cortical and medullary microcirculatory blood flow and renal function; and to find the value of ultrasonographic assessment of renal blood flow indices for evaluating prognosis in patients with sepsis.

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Key information

Conditions

Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Artery Blood Flow Renal Insufficiency Renal Microcirculation Renal Venous Return Urogenital Diseases Urologic Diseases

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Rongping Chen

Beijing, Beijing Municipality, 100730, China

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 18-85 years old; Control group: patients with non-acute kidney injury after ICU general surgery; Observation group: patients who met the diagnostic criteria of AKI: Scr elevation ≥26.5 umol/L within 48h; Scr elevation exceeding 1.5 times and more than the basal value within 7d; and decrease in urine output (<0.5 ml/kg/h) with a duration of 6h or more.

Exclusion criteria

  • Those who did not meet the inclusion criteria or refused to be enrolled; patients with underlying end-stage renal disease or requiring long-term dialysis; renal transplant patients; patients with other underlying systemic diseases causing renal dysfunction (SCr > 88.4 umol/L); those who were unable to obtain a clear renal ultrasound view; those with suspected contrast allergy; those with pulmonary arterial systolic blood pressure ≥ 90 mm Hg; and those who were pregnant or breastfeeding women.

Treatment and study plan

Primary outcomes

  1. 30-day major renal adverse events

    Time frame: 30-day

    Follow-up of patients with prognostic indicators of renal function within 30 days of enrolment, such as blood creatinine and the need for renal replacement therapy.

  2. Renal artery blood flow

    Time frame: Day 1,Day 3,Day 5, Day 7

    Ultrasound assessment of renal artery resistance index, and renal artery blood flow.

  3. Renal venous return

    Time frame: Day 1,Day 3,Day 5, Day 7

    Ultrasonographic assessment of renal venous reflux profiles.

  4. renal microcirculation

    Time frame: Day 1,Day 3,Day 5, Day 7

    Evaluation of renal microcirculation by ultrasonography.

Sponsors and collaborators

Lead sponsor

Peking Union Medical College Hospital

Other

Registry information

Official study title

Characteristics of Renal Blood Flow in AKI Patients With Sepsis and Its Clinical Significance

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Oct 19, 2023
Registry last updated
Feb 9, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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