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NCT Number: NCT05955976

Characteristics of Hoffa Adipose Tissue and Intramuscular Adipose Tissue in the Quadriceps Muscle

Over the last few years, it has been suggested that Knee Ostheoarthritis (KOA) incidence and progression could potentially be related to skeletal muscle characteristics. In particular, weakness of the quadriceps muscle would be a key determinant of KOA. However the mechanisms underpinning the influence of skeletal muscle in the pathophysiology of ostheoarthritis (OA) are poorly understood.

Crosstalk between skeletal muscle and structures around and in the joint is of interest. In physical deconditioning and aging, it has been reported that skeletal muscle can be replaced by adipose tissue. Several factors involved in the development of OA but also of adipose tissue may be involved in these muscular changes. Of interest, in patients with KOA, quadriceps weakness is an ubiquitous clinical finding. Infiltration of adipose tissue in skeletal muscle has been shown to affect muscle strength and mobility and be linked to cartilage volume loss and the occurrence/progression of KOA.

The main objective of this study is to compare the characteristics of the Hoffa tissus and the intamuscular fat (IMF) tissus in the quadriceps muscle in patients with gonarthrosis requiring total knee prosthesis.

This is a single-centre study based on a collection of surgical waste and is categorized as Research Not Involving Human subjects.

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Key information

Conditions

Osteo Arthritis Knee

Age range

40 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Nice University Hospital

Nice, 06000, France

Location status: Recruiting

Location contact

Christian ROUX

PRINCIPAL_INVESTIGATOR

Christian Roux

CONTACT

[email protected]

0492035491

Jean-François GONZALEZ

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patient, aged between 40 and 85 years
  • Patient having a confirmed diagnosis of knee ostheoarthritis
  • Patient undergoing a surgery for a total knee prosthesis for knee ostheoarthritis

Exclusion criteria

-

Treatment and study plan

Biopsy

Other

biopsy

Primary outcomes

  1. Comparison between Hoffa tissue and intramuscular fat tissue (quadriceps): adipose tissue size differences

    Time frame: 4 months

    size mesured in mm

  2. Comparison between Hoffa tissue and intramuscular fat tissue (quadriceps): lipid levels

    Time frame: 4 months

    level mesured in %

  3. Comparison between Hoffa tissue and intramuscular fat tissue (quadriceps):fibrotic tissue

    Time frame: 4 months

    rate mesured in %

Study contacts

Contact information is provided by the study sponsor or research team.

Christian ROUX, PUPH

CONTACT

[email protected]

0492035491

Jean-François GONCALVEZ, PUPH

CONTACT

[email protected]

0492035963

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Nice

Other

Registry information

Official study title

Study to Compare the Characteristics of Hoffa Adipose Tissue and Intramuscular Adipose Tissue in the Quadriceps Muscle

Acronym: ADIPENIGME

Important dates

Study start
2023
Primary completion
2023
Study completion
2027
First posted
Jul 21, 2023
Registry last updated
Jun 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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