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NCT Number: NCT03753594

Changes of Regional Tissue Oxygenation Saturation After Successful Femoral Nerve Block

Regional tissue oxygenation saturation has been shown to increase in innervated regions after sympathetic block. The aim of this prospective observational study was to evaluate the changes of regional tissue oxygenation saturation by near-infrared spectroscopy after successful femoral nerve block with ropivacaine and determine whether the changes of regional tissue oxygenation saturation can be affected by the concentration of ropivacaine.

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Key information

Conditions

Anesthesia, Local

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Union Hospital

Wuhan, Hubei, China

About this study

Successful peripheral nerve blocks induce sympathetic blockade, which increases local blood flow by vasodilation. The relationship between successful femoral nerve block and the variation of regional tissue oxygenation saturation was unclear.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Informed consent
  • American Society of Anesthesiologists physical statusⅠ-Ⅱ
  • Undergo elective elective knee arthroscopy with peripheral nerve block

Exclusion criteria

  • Refusal to participate in the study
  • BMI>35
  • Any contraindications to peripheral nerve block such as coagulation abnormalities, •Allergy to local anaesthetics, peripheral neuropathy

Treatment and study plan

tissue oxygenation saturation

Device

tissue oxygenation saturation

Primary outcomes

  1. Regional tissue oxygenation saturation after successful femoral nerve block

    Time frame: at 5-minute intervals till 30 minutes after regional block

    rSO2

Secondary outcomes

  1. Pinprick sensory scores

    Time frame: 5 minute before regional block and at 5-minute intervals till 30 minutes after regional block

    A 3-level scale was used to grade the intensity of sensory block using pinprick stimulation: 0=normal sensation; 1=analgesia; 2=anesthesia.

Sponsors and collaborators

Lead sponsor

Huazhong University of Science and Technology

Other

Registry information

Official study title

Changes of Regional Tissue Oxygenation Saturation After Successful Femoral Nerve Block With Ropivacaine at Different Concentrations

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Nov 27, 2018
Registry last updated
May 13, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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