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NCT Number: NCT06860061

Changes of Higher-Order Aberrations After Different Types of LASIK in Myopia

This prospective comparative interventional study will enroll patients with low and moderate myopia who seek laser vision correction at Sohag Center for LASIK and Corneal Surgeries, Sohag, Egypt. Eyes included will be divided into 3 groups according to the type of refractive surgery used (conventional LASIK, Femto-LASIK and PRK) and each group will be subdivided into 2 groups according to the degree of myopia (low and moderate).

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Key information

Conditions

Conventional LASIK, Femto-LASIK and PRK in Low and Moderate Myopia

Age range

18 week–45 week

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age: 18 - 45 years old.

Refraction:

Low and moderate grades of myopia will be included:

(According to manifest refraction) low ([0] - ≤ [-3] diopters) Moderate ([-3] - ≤ [-6] diopters) With cylinder ≤ [-1.5] diopters.

Exclusion criteria

Any ocular surgery or medication, corneal opacities, pregnancy, lactation and keratoconus.

Treatment and study plan

Laser Refractive Surgery

Procedure

This prospective comparative interventional study will enroll patients with low and moderate myopia who seek laser vision correction at Sohag Center for LASIK and Corneal Surgeries, Sohag, Egypt. Eyes included will be divided into 3 groups according to the type of refractive surgery used (conventional LASIK, Femto-LASIK and PRK) and each group will be subdivided into 2 groups according to the degree of myopia (low and moderate).

All patients will be subjected to routine comprehensive preoperative examinations including manifest uncorrected distant visual acuity (UCDVA), best corrected distant visual acuity (BCDVA), slit-lamp examination, intraocular pressure, and fundus examination.

Corneal topography and corneal aberrometry will be performed on all patients using Sirius's Scheimpflug-Placido topography (CSO, Florence, Italy). The CSO topography system analyzes a total of 6144 corneal points of a corneal area within a circular annulus outlined by an inner radius of 0.33 mm and an outer

Primary outcomes

  1. Changes of corneal higher-order aberrations

    Time frame: 1 year

    Corneal aberrometry will be performed using Sirius's Scheimpflug-Placido topography (CSO, Florence, Italy).

  2. Changes of total ocular higher-order aberrations

    Time frame: 1 year

    Wavefront refraction will be acquired by the iDesign aberrometer (Hartmann-Shack Aberrometer)

Study contacts

Contact information is provided by the study sponsor or research team.

ahmed abdeen, Master

CONTACT

[email protected]

+201003700245

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Changes of Corneal and Total Ocular Higher-Order Aberrations After Conventional LASIK, Femto-LASIK and PRK in Low and Moderate Myopia

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Mar 5, 2025
Registry last updated
Mar 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.