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OpenTrials
Completed

NCT Number: NCT05650398

Changes in Tactile Perception in People With Segmental Exclusion Syndrome

Segmental exclusion syndrome is characterised by the non-use or under-use of a limb segment, most oftenly reported in the distal part, following an injury, without affecting the central nervous system. This syndrome has an important negative impact on the daily life of affected subjects; however, it remains poorly studied, particularly in terms of pathophysiology, and its management is still not specific. Currently, the main pathophysiological hypothesis is an alteration of the afferences related to a dysfunction of the sensorimotor loop. An hypothesis is that this dysfunction could concern the level of tactile perception and that the damage to the distal light touch receptors could play a role in the pathophysiology. The protocol is based on the performance of tests that explore different aspects of light touch: passive, active, dynamic and static sensitivity.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Institut Régional de Médecine Physique et de Réadaptation

Nancy, 54000, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • No history of upper limb involvement
  • Confirmed diagnosis of segmental exclusion > 3 months after injury (2 items assigned to 400 points)
  • Able to understand simple orders

Exclusion criteria

  • Central neurological involvement after the initial or pre-existing injury
  • Truncal nerve damage
  • Presence of psychiatric pathology
  • Communication and/or comprehension disorders
  • Presence of other pathology that may lead to sensory disorders (complicated diabetes, ductal syndrome, ...)

Treatment and study plan

Primary outcomes

  1. Difference in passive sensitivity discrimination orientation threshold between each hand in static condition.

    Time frame: once during the one-day evaluation session

    Difference in thresholds of sensitive discrimination between the two hands in the Grating Orientation Task (mm)

  2. Difference in passive sensitivity discrimination threshold between each hand in static condition.

    Time frame: once during the one-day evaluation session

    Difference in thresholds of sensitive discrimination between the two hands in the Static Two Points discrimination test (mm)

  3. Difference in passive sensitivity discrimination of pressure threshold between each hand in static condition.

    Time frame: once during the one-day evaluation session

    Difference in thresholds of sensitive discrimination between the two hands in the monofilament test (Newton)

  4. Difference in passive sensitivity discrimination threshold between each hand in dynamic condition.

    Time frame: once during the one-day evaluation session

    Difference in thresholds of sensitive discrimination between the two hands in Moving Two-Points Discrimination Test (mm)

Secondary outcomes

  1. Difference in active sensitivity discrimination threshold between each hand in dynamic condition.

    Time frame: During the evaluation session

    Percentage of correct answers to the bar test in both groups.

Sponsors and collaborators

Lead sponsor

Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est

Other

Registry information

Important dates

Study start
2022
Primary completion
2025
Study completion
2025
First posted
Dec 14, 2022
Registry last updated
Aug 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.