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NCT Number: NCT06107959

Changes in Resting Metabolic Rate Following Orthopedic Surgery

This project is intended to determine the magnitude and duration of RMR changes in patients receiving orthopedic surgery. The result will help to guide postoperative nutrition recommendations in patients receiving orthopedic surgery.

Recruiting

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Key information

Conditions

Metabolism; Disorder, Postprocedural Post Operative Nutrition Resting Metabolic Rate

Age range

15 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The University of Kansas Medical Center

Kansas City, Kansas, 66160, United States

Location status: Recruiting

Location contact

Sharon Bradshaw

CONTACT

[email protected]

About this study

Surgery produces a catabolic response in the body that shifts metabolism from glucose to fat and protein. Despite no studies examining ACLR, studies of other orthopedic surgeries demonstrate increased postoperative energy expenditure, as well as a shift to beta-oxidation. Additionally, in most patients, these changes reverted to baseline within six weeks, although a subset of patients did not return to baseline until beyond 12 weeks.

This project will improve our understanding of magnitude and duration of RMR changes following orthopedic surgery, and the subsequent perioperative dietary suggestions that should be made to improve patient outcomes. Currently, postoperative dietary suggestions are not surgery nor patient specific. Determining how orthopedic surgery effects RMR will help to personalize perioperative treatment, rehabilitation, and recovery.

Better understanding the change in RMR following orthopedic surgery and implementing more accurate dietary modifications will help to ensure positive outcomes and control of infection following orthopedic surgery.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Any individual over 15 undergoing an orthopedic surgery.

Exclusion criteria

  • Pregnant female
  • < 15 years old

Treatment and study plan

Pre-surgical nutrition, hydration, RMR, and body composition assessments

Other

Urine sample, InBody device platform, Metabolic cart with hood to collect RMR.

Post-surgical nutrition, hydration, RMR and body composition assessments

Other

Same as pre-surgical tests at 1 week, 3 weeks, 6 weeks, and 12 weeks follow up time points.

Primary outcomes

  1. To determine the magnitude of the change in RMR of patients receiving orthopedic surgery.

    Time frame: 12 weeks

    RMR = (9.99 X actual weight*)+ (6.25 X height*) - (4.92 X age) - 161*use weight in kilograms (kilogram), height in centimeters (cm).

  2. To observe the amount of time it takes the RMR to return to baseline.

    Time frame: 12 weeks

    calculation in number of weeks

Study contacts

Contact information is provided by the study sponsor or research team.

Sharon Bradshaw

CONTACT

[email protected]

913-945-6289

Sponsors and collaborators

Lead sponsor

University of Kansas Medical Center

Other

Registry information

Important dates

Study start
2023
Primary completion
2027
Study completion
2027
First posted
Oct 30, 2023
Registry last updated
Jun 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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