Changes in Liver Function After Stereotactic Body Radiation Therapy Measured by PET/CT

Patients treated with stereotactic radiotherapy for liver tumors undergo PET/CT using the galactose analogue 18-F-deoxy-galactose (FDGal) before and after radiotherapy. This technique provides volumetric mapping of liver function and it allows quantisation of liver function. The method may be used for selection of patients for stereotactic radiotherapy of liver tumors, for determination of radiation induced liver dysfunction and may be included into the treatment planning process of stereotactic radiotherapy.

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Key information

Conditions

Hepatocellular Carcinoma Adenocarcinoma Carcinoma Carcinoma, Hepatocellular Cholangiocarcinoma Digestive System Diseases Digestive System Neoplasms Liver Diseases Liver Neoplasms Metastases Neoplasm Metastasis Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Neoplastic Processes Pathologic Processes Pathological Conditions, Signs and Symptoms Stereotactic Body Radiotherapy

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Aarhus University Hospital

Aarhus C, 8000, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

liver tumor
referred for stereotactic radiation therapy
age > 18 years

Exclusion criteria

Impaired kidney function
Pregnancy

Treatment and study plan

Measuring liver function by PET/CT

Other

Measuring liver function by use of FDGal and PET/CT before, 1 month and 3 months after stereotactic radiotherapy for liver tumors

Primary outcomes

Uptake of FDGal

Time frame: Before, 1 month and 3 months after stereotactic radiotherapy

Volumetric uptake of FDGal can be measured is measured by PET/CT

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Collaborators

Danish Cancer Society

Registry information

Official study title

Radiation Induced Change of Liver Function Measured by Uptake of the Galactose Analogue FDGal and PET/CT

Important dates

Study start: 2010
Primary completion: 2016
Study completion: 2016
First posted: Oct 4, 2010
Registry last updated: Oct 30, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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