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OpenTrials
Completed

NCT Number: NCT00734266

Changes in Leukotrienes During Cardiac Surgery in Patients With Chronic Obstructive Pulmonary Disease

The hypotheses of this study are that:

* Production and release of inflammatory substances called leukotrienes are increased during heart surgery with use of a heart-lung machine in humans; * The increase in these leukotrienes levels after heart surgery is higher in patients with bronchitis and/or emphysema than in patients without previous history of lung disease; * Levels of leukotrienes are directly correlated with worsening of lung function during and after heart surgery.

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Key information

Conditions

Lung Dysfunction Chronic Disease Disease Attributes Inflammatory Response During Cardiac Surgery Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

In this project, we will test the hypothesis that cys-leukotrienes are released and correlated with the impairment of the lung function after cardiac surgery in patients with COPD. If such hypothesis is substantiated in the study, it would allow us to propose the use of leukotriene inhibitors in the peri-operative period to improve pulmonary function and to decrease complications after cardiac surgery in COPD patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients schedules to undergo cardiac surgery with use of CPB.

Exclusion criteria

  • inability to provide consent;
  • previous diagnosis of asthma;
  • acute pre-operative respiratory failure;
  • emergency surgery.

Treatment and study plan

Primary outcomes

  1. urine cysteinyl leukotriene

    Time frame: intra-operative

Sponsors and collaborators

Lead sponsor

Massachusetts General Hospital

Other

Collaborators

  • Merck Sharp & Dohme LLC

Registry information

Important dates

Study start
2007
Primary completion
2010
Study completion
2010
First posted
Aug 14, 2008
Registry last updated
Mar 6, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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