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OpenTrials
Completed

NCT Number: NCT00452283

Changes in Eye Pressure and Anterior Chamber Depth With Oral Endothelin Antagonist Therapy

There is growing evidence that a cause of glaucoma is linked to circulatory problems and poor auto-regulation of blood flow to the optic nerve. Pulmonary hypertension (PH)is a disease characterized by low oxygen levels in the blood and altered blood circulation. The decrease in oxygen delivery to the optic nerve could lead to the loss of nerve fiber layer(NFL)in the retina and the resulting visual field compromise. This situation is characteristic of glaucoma. The ability to identify NFL thinning early could lead to earlier diagnosis of glaucoma and more effective treatment to limit dysfunction from visual field loss.

We hypothesize that the rate of structural damage to the NFL, a feature of glaucoma, is higher in patients with PH than expected in healthy populations lacking this disease.

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Key information

Conditions

Glaucoma Cardiovascular Diseases Eye Diseases Hypertension Hypertension, Pulmonary Lung Diseases Ocular Hypertension Pulmonary Hypertension Respiratory Tract Diseases Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Colorado Eye Center

Aurora, Colorado, 80045, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosed with pulmonary hypertension
  • between the ages of 18 and 80 years
  • ability to undergo the various ocular exams.

Exclusion criteria

  • patients with other diseases that could affect the nerve fiber layer
  • special populations; ie children, pregnancy, lactating females, prisoners

Treatment and study plan

Primary outcomes

  1. Occurence of nerve fiber layer abnormalities

    Time frame: Single Exam

Secondary outcomes

  1. Optic Nerve Head Structure

    Time frame: Single Exam

Other outcomes

  1. Visual Field Defects

    Time frame: Single Exam

  2. Retinal Blood Flow Changes

    Time frame: Single Exam

Sponsors and collaborators

Lead sponsor

University of Colorado, Denver

Other

Registry information

Official study title

The Effect of a Systemic Non-selective Endothelin Antagonist on Intraocular Pressure and Anterior Depth in Pulmonary Hypertension Patients.

Important dates

Study start
2007
Primary completion
2011
Study completion
2011
First posted
Mar 27, 2007
Registry last updated
Jan 31, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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