Changes in Elastic Properties of Descending Thoracic Aorta After Ascending Aorta Replacement

The aim of our study was to evaluate the impact of aortic root replacement by a graft on the elastic properties of the descending thoracic aorta using cardiac Magnetic Resonance Imaging (MRI) and automatic post-processing.

Nineteen patients were operated on an aortic root aneurysm and a cardiac MRI allowing aortic compliance measurement was performed before and after surgery. Images were acquired with a 1.5 T MRI with only one additional sequence to a conventional aortic MRI protocol.

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Key information

Conditions

Aortic Surgery

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

About this study

Observational and retrospective trial on medical data only. The patients are operated of planned aortic root aneurysm without additional intervention.

The pre and postoperative cardiac MRI are planned in standard of care.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

> 18 years
Elective patient
Ascending aorta replacement with graft

Exclusion criteria

Prior cardiac surgery
Contraindication to performing cardiac MRI

Treatment and study plan

Ascending aorta replacement with graft

Procedure

Patient with planned Ascending aorta replacement with graft

Other names: cardiac MRI

Primary outcomes

Aortic compliance of descending aorta (mm2/mmHg)

Time frame: post-operative cardiac MRI performing between 12 and 24 months

Aortic elastic properties of the descending aorta before and after aortic root replacement using cardiac MRI.

Aortic compliance is a local measurement of elastic properties which is obtained with cardiac MRI images by computer processing.

Secondary outcomes

Aortic compliance of ascending aorta (mm2/mmHg)

Time frame: post-operative cardiac MRI performing between 12 and 24 months

Aortic elastic properties of the ascending aorta before and after aortic root replacement using cardiac MRI.

Aortic compliance is a local measurement of elastic properties which is obtained with cardiac MRI images by computer processing.

Sponsors and collaborators

Lead sponsor

Centre Hospitalier La Chartreuse

Other

Collaborators

BOUCHOT Olivier
JAZAYERI Aline
JAZAYERI Saed
MALAPERT Ghislain
PETROSYAN Andreanik

Registry information

Official study title

Impact of Ascending Aorta Replacement by Graft on Elastic Properties of Descending Thoracic Aorta Evaluated by Cardiac Magnetic Resonance Imaging

Important dates

Study start: 2014
Primary completion: 2019
Study completion: 2019
First posted: Jan 25, 2019
Registry last updated: Jan 25, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed