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OpenTrials
Completed

NCT Number: NCT04146259

Changes in Circulating Sclerostin Levels During Acute Postsurgical Hypoparathyroidism

To investigate changes in sclerostin levels following acute post-thyroidectomy hypoparathyroidism

Completed

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Key information

Conditions

Hypoparathyroidism Postprocedural Endocrine System Diseases Hypoparathyroidism Parathyroid Diseases Sclerosteosis

Age range

19 year and older

Sex eligibility

Female

Study type

Observational

Primary location

Symeon Tournis

Athens, 14561, Greece

About this study

Female patients with thyroid disorders, referred to the Department of Head and Neck Surgery, at Metaxa Anti-Cancer Hospital of Piraeus, for total thyroidectomy.

Based on the development of biochemical hypocalcemia (cCa < 8.4 mg/dl), subjects were divided into 2 groups: Group A: without postsurgical hypoparathyroidism that served as controls and group B: subjects, with acute postsurgical hypoparathyroidism.

Blood collections were performed in the morning after an overnight fast, in at least 3 different time points; preoperatively, 1st postoperative day and 7th postoperative day for the detrmination of sclerostin levels

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Indication for total thyroidectomy

Exclusion criteria

  • parathyroid disorders, chronic kidney disease (eGFR< 60 ml/min), treatment with antiosteoporosis drugs, rheumatic disease and history of long term (>1 month) or current corticosteroid use

Treatment and study plan

calcium carbonate and alphacalcidol

Drug

treatment for hypocalcemia

Primary outcomes

  1. change in circulating serum sclerostin levels (pmol/L) during the observation period

    Time frame: 7 days

    change in circulating serum sclerostin levels (pmol/L)during the observation period

Secondary outcomes

  1. the between groups difference in % changes of circulating sclerostin

    Time frame: 7 days

    the between groups difference in % changes of circulating sclerostin

Sponsors and collaborators

Lead sponsor

University of Athens

Other

Registry information

Important dates

Study start
2017
Primary completion
2018
Study completion
2019
First posted
Oct 31, 2019
Registry last updated
Nov 1, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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