Changes in Ciliary Body Thickness in Patients With Diabetic Macular Edema After Vitrectomy

A diabetic macular edema group consisted of diabetic patients who underwent PPV for diffuse diabetic macular edema. A epiretinal membrane group, a surgical control group, consisted of non-diabetic patients with epiretinal membrane who underwent pars plana vitrectomy. A healthy control was also included for the comparison of preoperative ciliary body thickness. Ciliary body thickness was measured using ultrasound biomicroscopy, and central macular thickness was determined using optical coherence tomography. The visual outcome, ciliary body thickness, and central macular thickness were compared between groups before and 1, 2, and 4 months after pars plana vitrectomy and the correlations between the central macular thickness and ciliary body thickness and best corrected visual acuity were determined.

Inclusion criteria

for diabetic macular edema group:

• Diabetic macular edema with preoperative central macular thickness > 300 μm on optical coherence tomography
• Macular edema that was not associated with an epiretinal membrane or traction membrane
• No combined traction retinal detachment or vitreous hemorrhage
• No signs of ocular inflammatory disease on preoperative examination
• Phakic eye
• An axial length between 22.0 mm and 25.0 mm

Exclusion criteria

for diabetic macular edema group:

• Patients with uveitis, inflammatory connective tissue disorders or a history of previous ocular surgery
• Long-term application of topical medication, a history of intravitreal steroid or anti-VEGF injection within 3 months before vitrectomy

Inclusion criteria

for epiretinal membrane group:

• Non-diabetic patients with an epiretinal membrane who were scheduled for vitrectomy
• No ocular or systemic disease other than epiretinal membrane

Inclusion criteria

for healthy group:

• No diabetes
• No ocular disease other than cataract