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OpenTrials
Completed

NCT Number: NCT00394108

Changes in Cerebrovascular Reactivity During Cognitive Activation After Cardiopulmonary Bypass: Relation With Intraoperative Embolic Load and Postoperative Neuropsychological Dysfunctions

The study aims to evaluate neuropsychological disorders in CABG patients. Measurements are performed 1 day before, 6 days, 6 months and 3-5 years after the surgery. The relation with cerebrovascular reactivity and embolic load (measured by transcranial Doppler Ultrasonography) is evaluated. Two surgery techniques (on- and off-pump CABG) are compared.

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Key information

Conditions

CABG-patients

Age range

18 year–69 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Hospital Ghent

Ghent, 9000, Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • CABG-patients (not urgent)
  • < 70 years old
  • Righthanded

Exclusion criteria

  • Neurological or psychiatric disease
  • Psychoactive medication
  • Valve operation

Treatment and study plan

Determination of neuropsychological status

Procedure

Primary outcomes

  1. Neuropsychological status

    Time frame: after 6 days, 6 months and 3-5 years

Secondary outcomes

  1. Relation with intra-operative embolic load

Sponsors and collaborators

Lead sponsor

University Ghent

Other

Collaborators

  • Fund for Scientific Research, Flanders, Belgium

Registry information

Important dates

Study start
1999
Study completion
2002
First posted
Oct 31, 2006
Registry last updated
Dec 28, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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