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NCT Number: NCT06466681

Changes in Attentional Control After a Focal Seizure.

Epilepsy is frequently associated with cognitive and attentional disorders. Several studies have pointed out that there are modifications of brain activity in resting state during peri-ictal period in EEG and functional MRI. However, to date, no study has assessed the changes in attentional control after a seizure. The investigators hypothesize that a localized discharge is associated with a disorganization of the networks engaged in attentional control. In this regard, the investigators propose a prospective longitudinal study assessing the changes in attentional control after a focal seizure.

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Key information

Conditions

Temporal Lobe Epilepsy Brain Diseases Central Nervous System Diseases Epilepsies, Partial Epilepsy Epilepsy, Frontal Lobe Epilepsy, Temporal Lobe Epileptic Syndromes Frontal Lobe Epilepsy Nervous System Diseases Others Subtypes

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age superior to 18 and under 80
  • Focal epilepsy with indication to pre-surgery work-up and 5 days programmed hospitalization dedicated to this work-up
  • Normal global cognitive performance (standard progressive Raven matrices score > 5th percentile)
  • Be affiliated to the social security system
  • Have signed an informed consent

Exclusion criteria

  • Pregnancy or breastfeeding
  • Not able to give consent (Article 1121-8 of the CSP)
  • Vulnerable person
  • Being deprived of liberty by judicial or administrative decision (Article L 1121-6 of the CSP)
  • Guardianship
  • Have a high probability of not respecting the protocol or of abandoning the study
  • Absence of any epileptic seizure recorded during the hospitalization
  • Recurrent seizures preventing the recording of at least 24 hours without any seizure following a seizure.

Treatment and study plan

All included subjects

Other

Administration of the subtest of divided attention of the Test of Attentional Performance (TAP), recording of the event related potentiels N200 and P300, measure of the variation of power in several frequency bands (theta, alpha and beta) and measure of the high-resolution EEG connectivity during an attentional task at several time-points : a first time during interictal period (no seizure for more than 24 hours) and 1, 3, 6 and 24 hours after a focal seizure.

Primary outcomes

  1. Subtest of divided attention of the Test of Attentional Performance (TAP)

    Time frame: 24 hours

    A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.

Secondary outcomes

  1. N200 amplitude and latency

    Time frame: 24 hours

    A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.

  2. Strength of EEG functionnal connectivity during an attentional task (global and regional)

    Time frame: 24 hours

    A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.

  3. Variation of power in several frequency bands (theta, alpha and beta) during an attentional task.

    Time frame: 24 hours

    A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.

  4. Magnetic resonance imaging functional connectivity.

    Time frame: up to 5 days

  5. Differences in N200 and P300 amplitude and latency recorded between different subgroups according to the epileptic focus.

    Time frame: 24 hours

    A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every day until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.

  6. P300 amplitude and latency

    Time frame: 24 hours

    A first time during interictal period (no seizure for more than 24 hours) (this first measure will be repeated every days until a seizure is recorded) and 1, 3, 6 and 24 hours after a focal seizure.

  7. Differences in strength of EEG functional connectivity during an attentional task recorded between different subgroups according to the epileptic focus.

    Time frame: 24 hours

  8. Differences in variation of power in several frequency bands (theta, alpha and beta) during an attentional task recorded between different subgroups according to the epileptic focus.

    Time frame: 24 hours

  9. Differences in magnetic resonance imaging functional connectivity recorded between different subgroups according to the epileptic focus.

    Time frame: 24 hours

Sponsors and collaborators

Lead sponsor

University Hospital, Lille

Other

Registry information

Acronym: ATTENTIONEPIF

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Jun 20, 2024
Registry last updated
Apr 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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