Change in Brain Metabolism and Cognitive Function by Aripiprazole

Dopamine receptor occupancy and brain metabolism were measured using positron emission tomography after the administration of aripiprazole. Working memory performance was also measured using N-back task.

The investigators explored the relationship between changes in brain metabolism and working memory performance.

Completed

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Key information

Conditions

Antipsychotics Brain Metabolism Cognition Dopamine Receptor Occupancy

Age range

19 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Seoul National University Hospital

Seoul, 110-744, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

healthy volunteers
right-handed

Exclusion criteria

any significant abnormality on routine lab
any psychiatric disease

Treatment and study plan

Aripiprazole

Drug

single oral administration of aripiprazole

Primary outcomes

Reaction time of correct response in N-back task

Time frame: 48 hrs after the administration of aripiprazole

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Official study title

The Relationship Between D2 Occupancy and Change in Frontal Metabolism and Working Memory Induced by Aripiprazole

Important dates

Study start: 2009
Primary completion: 2010
Study completion: 2012
First posted: Mar 26, 2012
Registry last updated: Mar 26, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed