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OpenTrials
Completed

NCT Number: NCT01699594

Change in Airway Responsiveness After Allergen Exposure

Exposure to allergens changes the way the airway responds to some stimuli (methacholine). The investigators will look at whether or not exposure to allergens changes the way the airway responds to a different stimuli (mannitol) and compare that with the known stimuli (methacholine).

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Key information

Conditions

Allergic Asthma Asthma Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Saskatchewan

Saskatoon, Saskatchewan, S7N 0W8, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • mild, allergic asthma
  • FEV1 greater than 70% predicted
  • methacholine PC20 less than or equal to 16mg/ml

Exclusion criteria

  • known sensitivity to mannitol or other excipient
  • diagnosis of any other respiratory or non respiratory disease/disorder that would preclude the individual from participating
  • recent thoracic, abdominal or eye surgery
  • recent allergen exposure (4 weeks), respiratory infection (6 weeks)
  • current immunotherapy
  • pregnancy
  • history of anaphylaxis
  • use of asthma therapies other than short acting beta agonist

Treatment and study plan

Mannitol

Drug

Indirect bronchoprovocation agent being compared to direct bronchoprovocation agent (methacholine)

Other names: Aridol

Methacholine Chloride

Drug

Direct bronchoprovocation agent being compared to indirect bronchoprovocation agent (mannitol)

Other names: Provocholine

Primary outcomes

  1. Change from baseline in airway responsiveness three hours after allergen exposure

    Time frame: Change from Baseline at 3 hours

Sponsors and collaborators

Lead sponsor

University of Saskatchewan

Other

Registry information

Official study title

Allergen Induced Increase in Indirect Non-allergic Bronchial Reactivity

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Oct 3, 2012
Registry last updated
Apr 9, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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