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NCT Number: NCT07215819

Cervical Sagittal Alignment and Clinical Outcomes in Chronic Neck Pain

This observational, cross-sectional study investigates the relationship between cervical sagittal alignment parameters, pain-related disability, and body awareness in patients with chronic neck pain. Adult patients aged 18-50 years who present with neck pain lasting at least 3 months and who have undergone a lateral cervical X-ray within the past 3 months will be included. Cervical sagittal parameters will be measured on radiographs, and participants will complete the Neck Disability Index (NDI) and the Fremantle Neck Awareness Questionnaire to evaluate disability and altered body perception.

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Key information

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Prof. Dr. Cemil Taşçıoğlu Şehir Hastanesi

Istanbul, Turkey (Türkiye)

About this study

Chronic neck pain is a common musculoskeletal problem associated with significant disability and reduced quality of life. Although structural and radiological parameters such as cervical sagittal alignment have been proposed as potential contributors to symptom severity, their association with clinical outcomes remains controversial. Altered body awareness, as assessed by the Fremantle Neck Awareness Questionnaire, represents an additional dimension that may influence symptom persistence and disability in these patients.

The aim of this study is to analyze the relationship between cervical sagittal alignment parameters, pain intensity, disability, and body awareness in patients with chronic neck pain. Eligible participants are adults aged 18-50 years with persistent neck pain for at least three months and who have undergone a lateral cervical X-ray within the last three months. Exclusion criteria include a history of cervical trauma or surgery, neurological or psychiatric disorders, inflammatory or systemic diseases, and conditions such as fibromyalgia or malignancy.

Pain intensity will be assessed using the Visual Analog Scale (VAS), disability with the Neck Disability Index (NDI), and body perception with the Fremantle Neck Awareness Questionnaire. Cervical sagittal alignment parameters will be measured retrospectively from the hospital's PACS system. By correlating radiographic findings with patient-reported outcomes, this study seeks to clarify the clinical relevance of cervical sagittal alignment and provide insight into its potential role in the management of chronic neck pain

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18-600 years (inclusive), women and men

Chronic neck pain ≥3 months in duration

Lateral cervical X-ray performed within the past 3 months

Exclusion criteria

  • History of cervical spine trauma or surgery

Cervical radiculopathy (history or current radicular neck/arm pain)

Systemic conditions: diabetes mellitus, inflammatory rheumatic disease, familial hyperlipidemia, malignancy, or fibromyalgia

Known neurological or psychiatric disorders

Treatment and study plan

Primary outcomes

  1. Neck Disability Index (NDI)

    Time frame: At baseline

  2. Fremantle Neck Awareness Questionnaire (FreNAQ-Neck)

    Time frame: At baseline

Sponsors and collaborators

Lead sponsor

Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization

Other

Registry information

Official study title

Cervical Sagittal Alignment and Its Association With Disability and Neck Awareness in Patients With Chronic Neck Pain

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Oct 14, 2025
Registry last updated
Mar 19, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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