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NCT Number: NCT06971575

Cervical Radiculopathy Imaging Using MRN With Electrodiagnostic Correlation

This project will study patients with cervical radiculopathy. We will evaluate the combined diagnostic and prognostic value of magnetic resonance neurography (MRN), electrodiagnostic (EDX) studies, and historical and physical clinical elements. Specifically, this project will explore whether these data individually or in combination correlate with response to procedural and non-procedural treatment.

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Key information

Conditions

Cervical Radiculopathy Nervous System Diseases Neuromuscular Diseases Peripheral Nervous System Diseases Radiculopathy

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospital for Special Surgery

New York, 10021, United States

Location status: Recruiting

Location contact

Carlo Milani, MD

SUB_INVESTIGATOR

J. Levi Chazen

CONTACT

[email protected]

212-774-7149

J. Levi Chazen, MD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients presenting with symptoms compatible with acute or subacute unilateral (one-sided) cervical radiculopathy and signs of clinical weakness
  • 18-60 years old at the time of evaluation
  • Symptom onset of 2 to 12 weeks leading up to baseline visit
  • Diagnosis of unilateral cervical radiculopathy, with or without spinal cord compression, based on signs and symptoms, physical exam and supported by MRI findings of radiculopathy (as evidenced by foraminal stenosis/narrowing) based on standard-of-care cervical spine MRI
  • Patients who have undergone or have planned electrodiagnostic testing at HSS prior to surgery

Exclusion criteria

  • Prior cervical surgery or instrumentation
  • Those who have had a prior episode of cervical radiculopathy
  • History of peripheral neuropathy or another acute or chronic neurodegenerative condition
  • History of stroke, cerebellar disease, or central nervous system disease
  • Contraindications to undergoing a standard MRI examination (e.g., pregnancy)
  • Patients presenting with bilateral cervical radiculopathy

Treatment and study plan

Magnetic resonance neurography

Diagnostic Test

Patients will undergo a cervical MRI with specialized magnetic resonance neurography sequences to evaluate the extraforaminal cervical nerve roots.

Primary outcomes

  1. Presence of abnormalities on nerve (MRN) imaging

    Time frame: Baseline

    Presence of abnormalities on cervical MRN imaging that correspond to clinical findings of cervical radiculopathy. This includes abnormalities in extraforaminal cervical nerve root intraneural T2 signal and DTI values.

  2. Relationship between abnormalities on imaging and electrodiagnostic assessment

    Time frame: Baseline

    The relationship between any abnormalities identified on nerve imaging (cervical MRN) and electrodiagnostic findings will be assessed.

Secondary outcomes

  1. Numeric rating scale (NRS) pain

    Time frame: Baseline, 3 months, 6 months, 12 months

    Current NRS pain will be assessed on 0-10 scales (10=worst pain).

  2. Neck Disability Index (NDI)

    Time frame: Baseline, 3 months, 6 months, 12 months

    NDI is scored on a 0-100% scale, with 100% representing complete disability.

Study contacts

Contact information is provided by the study sponsor or research team.

Carlo Milani, MD

CONTACT

[email protected]

J. Levi Chazen, MD

CONTACT

[email protected]

212-774-7149

Sponsors and collaborators

Lead sponsor

Hospital for Special Surgery, New York

Other

Registry information

Official study title

Cervical Radiculopathy Imaging Using MR Neurography With Electrodiagnostic Correlation

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
May 14, 2025
Registry last updated
Apr 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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