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OpenTrials
Completed

NCT Number: NCT03722953

Cerebrovascular Response to Acute Exercise

Cerebrovascular function and peripheral vascular function will be measured in healthy young adults, before and after acute bouts of aerobic exercise at various intensities.

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Key information

Conditions

Healthy Behavior Motor Activity Physical Activity

Age range

20 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Gymnasium-Natatorium

Madison, Wisconsin, 53706, United States

About this study

Acute bouts of aerobic exercise have been shown to enhance vascular reactivity of the peripheral circulation; however, the effects of a single exercise session on the cerebral circulation are unknown. This study will measure cerebrovascular function and peripheral vascular function before and after aerobic exercise at high and low intensities.

The research aims are:

  • To determine if a single bout of aerobic exercise acutely enhances cerebrovascular function
  • To determine the effect of aerobic exercise intensity and dose on cerebrovascular function in healthy adults.
  • To determine if the acute exercise-induced changes in cerebrovascular function are associated with acute exercise-induced changes in peripheral vascular function in healthy adults.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Between 20-40 years old
  • BMI < 30 kg/m2
  • Recreationally active
  • Experience running on a treadmill

Exclusion criteria

  • Current smoker
  • History or evidence of: hepatic disease, renal disease, hematological disease, cardiovascular disease, stroke/neurovascular disease, diabetes
  • Taking blood pressure medication
  • History of depression or other mood related disorders
  • Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)

Treatment and study plan

Control

Other
  • Ultrasound
  • Blood Pressure
  • Heart Rate
  • Oxygen Saturation

Aerobic Exercise

Other
  • Ultrasound
  • Blood Pressure
  • Heart Rate
  • Oxygen Saturation

Primary outcomes

  1. Cerebrovascular function

    Time frame: Change in cerebrovascular function: measurements occur at baseline and 90 minutes post aerobic exercise to quantify magnitude of change.

    Utilize ultrasound to measure a change in blood flow velocity in response to a breathing test

  2. Peripheral vascular function

    Time frame: Change in peripheral vascular function: measurements occur at baseline and 60 minutes post aerobic exercise to quantify magnitude of change.

    Utilize ultrasound to measure a change in brachial artery diameter in response to reactive hyperemia

Sponsors and collaborators

Lead sponsor

University of Wisconsin, Madison

Other

Registry information

Official study title

The Role of Shear Stress in the Cerebrovascular Response to Acute Exercise

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Oct 29, 2018
Registry last updated
Oct 2, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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