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Completed

NCT Number: NCT01029080

Cerebrovascular Autoregulation During Sepsis

The aim of the study is to correlate the dynamic cerebrovascular autoregulation by patients with sepsis with a sepsis-associated delirium.

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Key information

Conditions

Sepsis Confusion Delirium Infections Inflammation Mental Disorders Nervous System Diseases Neurobehavioral Manifestations Neurocognitive Disorders Neurologic Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Signs and Symptoms Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University medical centre Mainz

Mainz, 55131, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • clinical symptoms of sepsis, severe sepsis and septic shock
  • possibility for measurement of transcranial doppler ultrasound
  • age over 18 years

Exclusion criteria

  • preexisting cerebrovascular disease
  • preexisting immunological disease
  • traumatic brain injury
  • intracranial infectious disease
  • pregnancy

Treatment and study plan

No interventions

Other

No interventions

Primary outcomes

  1. Disturbed cerebrovascular autoregulation correlates with sepsis associated delir

    Time frame: 1 year

    The Index of autoregulation (Mx) was measured and correlated with the clinical incidence of a sepsis associated delir

Secondary outcomes

  1. Correlation between inflammatory parameters and disturbed cerebrovascular autoregulation

    Time frame: 1 year

  2. Correlation between inflammatory parameters and sepsis-associated delirium

    Time frame: 1 year

Sponsors and collaborators

Lead sponsor

Johannes Gutenberg University Mainz

Other

Registry information

Official study title

Dynamic Cerebrovascular Autoregulation During Sepsis and Sepsis-associated Delirium

Important dates

Study start
2009
Primary completion
2010
Study completion
2011
First posted
Dec 9, 2009
Registry last updated
Apr 15, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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