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NCT Number: NCT03919305

Cerebral Venous Thrombosis Cohort Study in China Mainland

This study was aimed to reveal the clinical features,natural history of the diseases and current therapeutic situations of cerebral venous thrombosis (CVT) in China mainland. Blood samples and cerebrospinal fluid samples will be collected after recruitment to reveal the pathological mechanisms of CVT and identify the biomarkers for CVT.

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Key information

Conditions

Cerebral Venous Sinus Thrombosis Cortical Vein Thrombosis Deep Cerebral Vein Thrombosis

Sex eligibility

All sexes

Study type

Observational

Primary location

Xuanwu Hospital, Capital Medical University

Beijing, China

Location status: Recruiting

Location contact

Min Li, MD, PhD

CONTACT

About this study

cerebral venous thrombosis (CVT) is caused by a clot in the cerebral vein, which resulted in an obstruction of the blood outflow. CVT mainly includes cerebral venous sinus thrombosis, deep cerebral vein thrombosis and cortical vein thrombosis. However, the epidemiological features of CVT in China mainland remained obscure. This study was aimed to establish a multicenter cohort recruiting patients with CVT across 31 provinces and municipalities in China mainland. Clinical features,natural history of the diseases and current therapeutic situations will be analyzed to reveal the epidemiological features of CVT. Blood samples and cerebrospinal fluid samples will be collected after recruitment to reveal the pathological mechanisms of CVT and identify the biomarkers for CVT. Patients will be followed-up at 1, 3, 6, 12 months from baseline to evaluate the clinical prognosis and therapeutic outcomes.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Cerebral venous sinus thrombosis, deep cerebral vein thrombosis and cortical vein thrombosis diagnosed by digital subtraction angiography (DSA), magnetic resonance venography (MRV), computed tomography venography (CTV) or high-resolution magnetic resonance imaging (HR-MRI).

Exclusion criteria

  • None of the patient, trustee or immediate family members signed the informed consent.

Treatment and study plan

Primary outcomes

  1. Death rate

    Time frame: 1 year from baseline

    A combination of death form of all causes

  2. Functional independence

    Time frame: 1 year from baseline

    Defined as modified Rankin score (0-5) equal to or lower than 2

  3. Recurrence of cerebral venous sinus thrombosis, deep cerebral venous thrombosis and cortical vein thrombosis

    Time frame: 1 year from baseline

    Diagnosed by DSA, MRV, CTV or HR-MRI

  4. Incidence of hemorrhagic complication

    Time frame: 1 year from baseline

    Extracranial hemorrhage (fall in hemoglobin of 2 gram/dl or more within 48 hours) or intracranial hemorrhage

  5. Incidence of sinus wall rupture

    Time frame: 1 year from baseline

  6. Incidence of acute ischemic stroke

    Time frame: 1 year from baseline

  7. Incidence of acute myocardial infarction

    Time frame: 1 year from baseline

  8. Incidence of pulmonary embolism

    Time frame: 1 year from baseline

  9. Incidence of deep venous thrombosis

    Time frame: 1 year from baseline

Secondary outcomes

  1. Incidence of epilepsy

    Time frame: 1 year from baseline

  2. Incidence of allergic reaction

    Time frame: 1 year from baseline

Study contacts

Contact information is provided by the study sponsor or research team.

Min Li, MD, PhD

CONTACT

[email protected]

+86-18701519698

Sponsors and collaborators

Lead sponsor

Capital Medical University

Other

Collaborators

  • Beijing Municipal Science & Technology Commission

Registry information

Acronym: CCC

Important dates

Study start
2019
Primary completion
2025
Study completion
2026
First posted
Apr 18, 2019
Registry last updated
Jun 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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