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Completed

NCT Number: NCT01781000

Cerebral Reorganization in Schizophrenia

The purpose of this study is to reveal the specific effects of computer-aided cognitive training on cerebral reorganization in schizophrenia

Completed

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Key information

Conditions

Schizophrenia Mental Disorders Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Konstanz

Konstanz, Baden-Wurttemberg, 78464, Germany

About this study

Impairment in cognitive functions is one of the main symptoms in schizophrenia and is currently one of the challenges in the treatment of the disease. In this study we compare effects of two computer-aided training programs. One focused on auditory perception and processing as a basic ability underlying higher order information processing. The other training focus on facial affect discrimination and working memory. Both trainings are computer-aided and time-intensive, including up to twenty sessions within four weeks.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of schizophrenia and disorders with psychotic features
  • Intact auditory perception
  • Intact visual perception

Exclusion criteria

  • Mental retardation
  • Age over 60
  • Insufficient German language knowledge

Treatment and study plan

Brain Fitness & Brain Training- Posit Science

Behavioral

Computer aided cognitive program designed for intensive training of auditory perception, memory and attention

Facial Affect Training- FAT

Behavioral

Computer-aided cognitive program designed for intensive training of facial affect discrimination, memory and attention

Treatment as Usual

Behavioral

standard treatment protocol of schizophrenia ward

Primary outcomes

  1. change from baseline at post-intervention (4-weeks) and 3-months in each to the primary outcome measures: neuropsychological test scores (MCCB), MEG alpha oscillations

    Time frame: baseline, post-intervention (after 4 weeks), 3-months follow-up

Secondary outcomes

  1. change from baseline in global functioning (GAF score) at 4 weeks and 3 months

    Time frame: baseline, post-intervention, 3-months follow-up

Sponsors and collaborators

Lead sponsor

University of Konstanz

Other

Registry information

Official study title

Training-induced Cerebral Reorganization in Schizophrenia

Important dates

Study start
2011
Primary completion
2014
Study completion
2014
First posted
Jan 31, 2013
Registry last updated
Nov 4, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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