Cerebral Dynamic Perfusion Study With Spectral CT in Patients Suspected of Stroke

* Generate a dynamic mapping of the distribution of iodine within the cerebral parenchyma in the patient suspected of acute ischemic disorder with the CT spectral scanner. * Correlate the anomalies of iodine mapping to the other parameters acquired during the classic dynamic infusion phase to define the ischemic area (MTT higher and rCBV normal) versus infarcted zone (MTT higher and rCBV decreased)

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Key information

Conditions

Stroke, Acute Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Stroke Vascular Diseases

Age range

50 year–95 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cliniques universitaires saint Luc

Brussels, 1200, Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical suspicion of hyperacute stroke (6 hours after onset of symptoms)
Age between 50 and 95 years
Weight: between 65 and 95 kg

Exclusion criteria

Documented or suspected allergy to IV iodinated contrast media
Renal impairment with creatinine clearance <60 ml / min
Hemorrhagic lesions or vascular abnormalities demonstrated on CT before contrast injection

Treatment and study plan

spectral CT

Radiation

Head spectral CT

Primary outcomes

Cerebral Blood Volume (CBV)

Time frame: from start of the study procedure (CT scan) through end of study procedure (from 15 minutes to 30 minutes)

CBV is measured in units of milliliters of blood per 100 g of brain and is defined as the volume of flowing blood for a given volume of brain.
Mean Transit Time (MTT)

Time frame: rom start of the study procedure (CT scan) through end of study procedure (from 15 minutes to 30 minutes)

MTT is measured in seconds and defined as the average amount of time it takes blood to transit through the given volume of brain.
Cerebral Blood Flow (CBF)

Time frame: rom start of the study procedure (CT scan) through end of study procedure (from 15 minutes to 30 minutes)

CBF is measured in units of milliliters of blood per 100 g of brain tissue per minute and is defined as the volume of flowing blood moving through a given volume of brain in a specific amount of time.

Sponsors and collaborators

Lead sponsor

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Other

Registry information

Acronym: AVC_AIGUS

Important dates

Study start: 2017
Primary completion: 2019
Study completion: 2019
First posted: May 14, 2019
Registry last updated: Nov 2, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed