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Completed

NCT Number: NCT01331382

Cerebral Blood Flow Effects of Resveratrol and Piperine in Humans

Resveratrol is associated with a plethora of physiological effects in humans, including modulation of cerebral blood flow, despite apparently poor bioavailability. This study investigated whether the physiological effects of resveratrol could be affected when co-supplemented with piperine, an alkaloid which may be able to enhance the bioavailability of resveratrol.

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Key information

Conditions

Healthy

Age range

18 year–35 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Brain performance and nutrition research centre, Northumbria university

Newcastle upon Tyne, Tyne and Wear, NE1 8ST, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Between the ages of 18-35 years old
  • Healthy
  • Non-smoker

Exclusion criteria

  • Not proficient in English
  • Taking medication or herbal supplements
  • Pregnant or breast feeding
  • Heavy caffeine consumer
  • History of head trauma, migraines, learning difficulties, ADHD, gastrointestinal problems.
  • Food allergies of intolerances

Treatment and study plan

Trans- resveratrol

Dietary Supplement

All 23 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 250mg resveratrol with 20mg piperine or placebo on separate days (with a 48hr-14 day wash-out period between each treatment) with the order dictated by Latin square. Treatment was in the form of powder and administered in capsule form, in a double blind manner.

Placebo (silica)

Other

All 23 participants who completed the study took part in 3 conditions; receiving either 250mg resveratrol, 250mg resveratrol with 20mg piperine or placebo on separate days (with a 48hr-14 day wash-out period between each treatment) with the order dictated by Latin square. Treatment was in the form of powder and administered in capsule form, in a double blind manner.

Primary outcomes

  1. Modulation of levels of total haemoglobin

    Time frame: 80 minutes following treatment administration

  2. Modulation of levels of deoxygenated haemoglobin

    Time frame: 80 minutes following treatment administration

  3. Modulation of levels of oxygenated haemoglobin

    Time frame: 80 minutes following treatment administration

Secondary outcomes

  1. Number of participants displaying significant modulation of cognitive performance

    Time frame: 40-80 minutes post dose

    Cognitive performance was assessed at baseline and then again 40 minutes post-treatment to assess if any changes had taken place.

Sponsors and collaborators

Lead sponsor

Northumbria University

Other

Registry information

Official study title

Effects of Resveratrol Alone or in Combination With Piperine on Cerebral Blood Flow Parameters and Cognitive Performance in Humans

Important dates

Study start
2010
Primary completion
2010
Study completion
2010
First posted
Apr 8, 2011
Registry last updated
Apr 8, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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