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NCT Number: NCT05843604

Cerebral and Cognitive Markers of Treatment Resistance in Obsessive Compulsive Disorder

This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.

Recruiting

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Key information

Conditions

OCD

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Centre Hospitalier Henri Laborit

Poitiers, France

Location status: Recruiting

Location contact

Damien Doolub, MD

CONTACT

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions)
  • Understand and accept the constraints of the study
  • Be a beneficiary or affiliated to a Health Insurance scheme

Exclusion criteria

  • Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998)
  • Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not exclusion criteria according to the M.I.N.I. version 5.0 (Sheehan et al., 1998)
  • Have a serious intercurrent pathology
  • Being a pregnant woman
  • Being a woman of childbearing age without effective contraception.
  • Being hospitalized under duress or on an outpatient basis in a care program
  • Being under judicial protection (reinforced curatorship, guardianship)

Treatment and study plan

Functional MRI

Other

Three cognitive tests will be performed in the MRI, namely a stroop task, an N-back task and a switching task

Primary outcomes

  1. Cerebral activity modification during N-back task

    Time frame: Day 1

    Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls

  2. Cerebral activity modification during Stroop task

    Time frame: Day 1

    Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls

  3. Cerebral activity modification during switching task (Monsell et Mizon task )

    Time frame: Day 1

    Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls

Study contacts

Contact information is provided by the study sponsor or research team.

Damien Doolub, MD

CONTACT

[email protected]

+33 (0)5 16 61 18

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Henri Laborit

Other

Registry information

Official study title

Cerebral and Cognitive Markers of Treatment Resistance in Obsessive-compulsive Disorder: Towards Personalization of Patient Care

Acronym: 3TOC

Important dates

Study start
2023
Primary completion
2027
Study completion
2027
First posted
May 6, 2023
Registry last updated
Jan 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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