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Completed

NCT Number: NCT02816034

Cerebellar Alterations in Individuals With a Cannabis Use Disorder

The purpose of this study is to investigate if individuals with a cannabis use disorder have an impaired cerebellar function by assessing possible alterations to their implicit adaptation during a visuomotor rotation task.

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Key information

Conditions

Cannabis Chemically-Induced Disorders Marijuana Abuse Mental Disorders Substance-Related Disorders

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients diagnosed with a Cannabis use disorder following Diagnostic and Statistical Manual (DSM-V) criteria.
  • Patients screen positive to cannabis in the urine analysis performed a week prior to assessment.
  • Right-handed patients.
  • Patients provide a signed consent.

Exclusion criteria

  • Patients with another current substance use disorder (with the exception of tobacco).
  • Patients with a visual impairment that has not been corrected.
  • Patients with a cognitive impairment such as mental retardation.
  • Patients with psychotic disorders.

Treatment and study plan

Visuo-motor rotation

Behavioral

Participant moves a cursor on a screen by sliding a pen over a digital tablet. Participants perform a center-out movement, aiming to a target that appears over one of a set of eight markers radially distributed. In several block of trials, the mapping of the pen position to the cursor is rotated.

Explicit strategy

Behavioral

Participant is provided with an explicit instruction as to how counteract the effects of the visuo-motor rotation via aiming to a marker adjacent target

Primary outcomes

  1. Directional error of hand trajectories towards a target

    Time frame: 1 day (a single session)

Secondary outcomes

  1. Reaction times

    Time frame: 1 day (a single session)

  2. Intrinsic Motivational Inventory

    Time frame: 1 day (a single session)

Sponsors and collaborators

Lead sponsor

Universitat Pompeu Fabra

Other

Collaborators

  • Hospital Clinic of Barcelona
  • Institut d'Investigacions Biomèdiques August Pi i Sunyer

Registry information

Official study title

Alterations in Cerebellar-dependent Adaptation Due to Cannabis Use Measured With an Explicit-implicit Visuo-motor Learning Paradigm

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Jun 28, 2016
Registry last updated
Nov 5, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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